CAS 13649-57-5

Deacetyldeflazacort

Description:

Deacetyldeflazacort is a synthetic glucocorticoid, primarily used for its anti-inflammatory and immunosuppressive properties. It is a derivative of deflazacort, which is itself a corticosteroid. The compound is characterized by its ability to modulate the immune response and reduce inflammation, making it useful in the treatment of various autoimmune diseases and conditions involving excessive inflammation. Deacetyldeflazacort exhibits a favorable pharmacokinetic profile, including good oral bioavailability and a relatively long half-life, which allows for convenient dosing regimens. Its mechanism of action involves binding to glucocorticoid receptors, leading to the regulation of gene expression that ultimately results in decreased production of pro-inflammatory cytokines. Additionally, it has been noted for having a lower incidence of certain side effects commonly associated with traditional corticosteroids, such as weight gain and adrenal suppression. However, like all corticosteroids, it should be used with caution due to potential side effects, particularly with long-term use.

Formula: C₂₃H₂₉NO₅

InChI: InChI=1S/C23H29NO5/c1-12-24-23(18(28)11-25)19(29-12)9-16-15-5-4-13-8-14(26)6-7-21(13,2)20(15)17(27)10-22(16,23)3/h6-8,15-17,19-20,25,27H,4-5,9-11H2,1-3H3/t15-,16-,17-,19+,20+,21-,22-,23+/m0/s1

InChI key: InChIKey=KENSGCYKTRNIST-RVUAFKSESA-N

SMILES: C(CO)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(OC(C)=N2)[H])([C@]4([C@]([C@@H](O)C3)([C@]5(C)C(CC4)=CC(=O)C=C5)[H])[H])[H]

Synonyms:

• (11,16)-11,21-Dihydroxy-2'-methyl-5'H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione
• (11β,16β)-11,21-Dihydroxy-2′-methyl-5′H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione
• (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8-trimethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]oxazol-2-one
• 21-Deacetyldeflazacort
• 21-Desacetyldeflazacort
• 5′H-Pregna-1,4-dieno[17,16-d]oxazole-3,20-dione, 11,21-dihydroxy-2′-methyl-, (11β,16β)-
• 5′β<span class="text-smallcaps">H</span>-Pregna-1,4-dieno[17,16-d]oxazole-3,20-dione, 11β,21-dihydroxy-2′-methyl-
• Deacetyldeflazacort
• Deflazacortalcohol
• L 6485
• 5′βH-Pregna-1,4-dieno[17,16-d]oxazole-3,20-dione, 11β,21-dihydroxy-2′-methyl-

21-Desacetyl Deflazacort ((11β,16β)-11,21-Dihydroxy-2'-methyl-5'H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione)

CAS: 13649-57-5

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₂₃H₂₉NO₅

Color and Shape: White Off-White Solid

Molecular weight: 399.20457

Ref: 45-1A02730

5'H-Pregna-1,4-dieno[17,16-d]oxazole-3,20-dione, 11,21-dihydroxy-2'-methyl-, (11β,16β)-

CAS: 13649-57-5

Formula: C₂₃H₂₉NO₅

Purity: 99%

Color and Shape: Solid

Molecular weight: 399.4801

Ref: IN-DA0011X8

21-Hydroxy Deflazacort (21-Desacetyl Deflazacort)

CAS: 13649-57-5

Formula: C₂₃H₂₉NO₅

Color and Shape: White To Off-White Solid

Molecular weight: 399.49

Ref: 4Z-D-312

21-deacetyldeflazacort

CAS: 13649-57-5

21-deacetyldeflazacort

Purity: ≥98%

Molecular weight: 399.48g/mol

Ref: 54-BUP03851

21-Desacetyldeflazacort

Controlled Product

CAS: 13649-57-5

Formula: C₂₃H₂₉NO₅

Color and Shape: Neat

Molecular weight: 399.48

Ref: 86-MM1224.02

21-deacetyldeflazacort

CAS: 13649-57-5

21-deacetyldeflazacort is a metabolite of Deflazacort, which is a systemic corticosteroid and a derivative of prednisolone.

Formula: C₂₃H₂₉NO₅

Purity: 99.96%

Color and Shape: Solid

Molecular weight: 399.48

Ref: TM-T29328

21-Desacetyl Deflazacort

Controlled Product

CAS: 13649-57-5

Stability Hygroscopic
Applications A metabolite of Deflazacort, a systemic corticosteroid, a derivative of prednisolone and used for rheumatoid arthritis and lupus.
References Hahn, T.J., et al.: Calcif. Tissue Int., 31, 109 (1980), Cavall-Perin, P., et al.: Eur. J. Clin. Pharmacol., 26, 357 (1984)

Formula: C₂₃H₂₉NO₅

Color and Shape: White To Off-White

Molecular weight: 399.48

Ref: TR-D288695

21-Desacetyl Deflazacort

CAS: 13649-57-5

Formula: C₂₃H₂₉NO₅

Molecular weight: 399.5

Ref: ST-EA-CP-D14002

21-Desacetyl Deflazacort-d6 (major)

Controlled Product

CAS: 13649-57-5

Applications Isotope labelled 21-Desacetyl Deflazacort (D288695), a metabolite of Deflazacort, a systemic corticosteroid, a derivative of prednisolone and used for rheumatoid arthritis and lupus.
References Hahn, T.J., et al.: Calcif. Tissue Int., 31, 109 (1980), Cavall-Perin, P., et al.: Eur. J. Clin. Pharmacol., 26, 357 (1984)

Formula: C₂₃D₆H₂₃NO₅

Color and Shape: Neat

Molecular weight: 405.517

Ref: TR-D288696

21-Desacetyl deflazacort

CAS: 13649-57-5

Deflazacort is a synthetic glucocorticoid that is used in the treatment of Duchenne and Becker muscular dystrophy. It has been shown to be effective for the management of inflammatory conditions such as asthma, allergies, and other allergic reactions. Deflazacort binds to and activates glucocorticoid receptors in humans. The drug undergoes rapid metabolism with a terminal half-life of about 1 hour. Deflazacort is eliminated by both urinary excretion and hepatic metabolism. This drug has pharmacokinetic properties that are similar to prednisolone, although it has a longer duration of action due to its slow hepatic clearance.

Formula: C₂₃H₂₉NO₅

Purity: Min. 95%

Molecular weight: 399.48 g/mol

Ref: 3D-FD21122