CAS 13649-88-2

Deflazacort

Description:

Deflazacort is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties, primarily used in the treatment of various inflammatory and autoimmune conditions. It is characterized by its ability to modulate the immune response and reduce inflammation, making it effective in conditions such as rheumatoid arthritis, lupus, and certain skin disorders. Deflazacort is known for its relatively lower side effects compared to other corticosteroids, particularly in terms of weight gain and adrenal suppression. The compound has a molecular formula that reflects its steroidal structure, which includes a cyclopentanoperhydrophenanthrene core. Its mechanism of action involves binding to glucocorticoid receptors, leading to the regulation of gene expression and subsequent modulation of inflammatory mediators. Deflazacort is typically administered orally and is available in various formulations, including tablets and syrups. Due to its pharmacological profile, it is often preferred in long-term management of chronic conditions where corticosteroid therapy is indicated.

Formula: C₂₃H₂₉NO₄

InChI: InChI=1/C23H29NO4/c1-12(25)23-19(28-13(2)24-23)10-17-16-6-5-14-9-15(26)7-8-21(14,3)20(16)18(27)11-22(17,23)4/h7-9,16-20,27H,5-6,10-11H2,1-4H3/t16-,17-,18-,19+,20+,21-,22-,23?/m0/s1

Synonyms:

• 11b,21-Dihydroxy-2'-methyl-5'bH-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione 21-acetate
• Deflazacort Intermediate
• (4Ar,4Bs,5S,6As,9Ar,10As,10Bs)-6B-Acetyl-5-Hydroxy-4A,6A,8-Trimethyl-4A,4B,5,6,6A,6B,9A,10,10A,10B,11,12-Dodecahydro-9-Oxa-7-Aza-Pentaleno[2,1-A]Phenanthren-2-One
• 2-(5-hydroxy-4a,6a,8-trimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]oxazol-6b-yl)-2-oxoethyl acetate
• 2-[(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-4a,6a,8-trimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]oxazol-6b-yl]-2-oxoethyl acetate
• (4aR,4bS,5S,6aS,9aR,10aS,10bS)-6b-acetyl-5-hydroxy-4a,6a,8-trimethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]oxazol-2-one
• (11β,16β)-11-hydroxy-2-methyl-5β-H-progna-1,4-dieno[17,16-d]Oxazolo-3,20-dione
• Pregna-1,4-Diene-11B-Ol-17A,16A-D-2-Methyl-Oxazoline-3,20-Dione

(11β,16β)-11-Hydroxy-2′-methyl-5′H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione

CAS: 13649-88-2

Formula: C₂₃H₂₉NO₄

Purity: 98.0%

Color and Shape: Solid

Molecular weight: 383.4807

Ref: IN-DA0011X7

21-Deacetoxy Deflazacort

CAS: 13649-88-2

Formula: C₂₃H₂₉NO₄

Color and Shape: White To Off-White Solid

Molecular weight: 383.49

Ref: 4Z-D-314

21-Desacetoxydeflazacort

Controlled Product

CAS: 13649-88-2

Formula: C₂₃H₂₉NO₄

Color and Shape: Neat

Molecular weight: 383.48

Ref: 86-MM1224.01

21-Deacetoxy Deflazacort-d3 (Major)

Controlled Product

CAS: 13649-88-2

Applications A labeled intermediate of Deflazacort (D228975), a systematic corticosteroid.
References Nathansohn, G. et al.: Steroids, 13, 365 (1969); Nathansohn, G., et al.: J. Med. Chem., 10,799 (1967), Schiatti, P., et al.: Arzneim. Forsch., 30, 1543 (1980),

Formula: C₂₃D₃H₂₆NO₄

Color and Shape: Neat

Molecular weight: 386.499

Ref: TR-D198002

21-Deacetoxy Deflazacort

Controlled Product

CAS: 13649-88-2

Applications An intermediate of Deflazacort (D228975), a systematic corticosteroid.
References Nathansohn, G. et al.: Steroids, 13, 365 (1969); Nathansohn, G., et al.: J. Med. Chem., 10,799 (1967), Schiatti, P., et al.: Arzneim. Forsch., 30, 1543 (1980),

Formula: C₂₃H₂₉NO₄

Color and Shape: Neat

Molecular weight: 383.48

Ref: TR-D198000

Deflazacort intermediate

CAS: 13649-88-2

Deflazacort intermediate is a complex compound that belongs to the chemical family of dibenzofurans. This compound is an intermediate for the synthesis of deflazacort, a corticosteroid. Deflazacort intermediate has shown potential in the synthesis of other compounds, such as antibiotics and anti-cancer drugs. It can also be used as a reactive building block for the synthesis of other chemical compounds. The use of this reagent is versatile and can be applied in research or industrial settings.

Formula: C₂₃H₂₉NO₄

Purity: Min. 97 Area-%

Color and Shape: Powder

Molecular weight: 383.48 g/mol

Ref: 3D-FD20816

21-Deacetoxy Deflazacort

CAS: 13649-88-2

Formula: C₂₃H₂₉NO₄

Molecular weight: 383.49

Ref: ST-EA-CP-D14005

21-Deacetoxy deflazacort

CAS: 13649-88-2

21-Deacetoxy deflazacort is a dehydrogenated derivative of Deflazacort, which is a glucocorticoid. As an inactive precursor, Deflazacort rapidly converts into the active metabolite, 21-Desacetyldeflazacort. This compound serves as both an anti-inflammatory and immunosuppressive agent.

Formula: C₂₃H₂₉NO₄

Color and Shape: Solid

Molecular weight: 383.48

Ref: TM-T201719