CAS 136553-81-6

B Q-123

Description:

B Q-123, identified by its CAS number 136553-81-6, is a chemical compound that has garnered attention in various fields, particularly in medicinal chemistry and pharmacology. It is characterized by its specific molecular structure, which contributes to its unique biological activity. B Q-123 is known to act as a selective antagonist of certain receptors, influencing various physiological processes. Its solubility, stability, and reactivity are important factors that determine its application in research and potential therapeutic uses. Additionally, B Q-123 may exhibit specific interactions with other biomolecules, which can be critical for its function in biological systems. Safety and handling guidelines are essential when working with this compound, as with any chemical substance, to mitigate any potential hazards. Overall, B Q-123 represents a significant compound in the study of receptor interactions and therapeutic development, although detailed information on its specific applications and effects may vary based on ongoing research.

Formula: C₃₁H₄₂N₆O₇

InChI: InChI=1/C31H42N6O7/c1-16(2)12-21-27(40)33-22(13-18-15-32-20-9-6-5-8-19(18)20)28(41)35-23(14-25(38)39)31(44)37-11-7-10-24(37)29(42)36-26(17(3)4)30(43)34-21/h5-6,8-9,15-17,21-24,26,32H,7,10-14H2,1-4H3,(H,33,40)(H,34,43)(H,35,41)(H,36,42)(H,38,39)

SMILES: CC(C)CC1C(=NC(Cc2c[nH]c3ccccc23)C(=NC(CC(=O)O)C(=O)N2CCCC2C(=NC(C(C)C)C(=N1)O)O)O)O

Synonyms:

• cyclo(D-asp-pro-D-val-leu-D-trp)
• Cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu)
• D-alpha-aspartyl-L-prolyl-D-valyl-N-[(2R)-1-(1H-indol-3-yl)-3-oxopropan-2-yl]-4-methylidene-L-norvalinamide
• cyclo(D-alpha-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl)
• Cyclo(Alpha-Aspartylprolylvalylleucyltryptophyl)
• Bq-123 Sodium Salt
• Cyclo(D-Asp-L-Pro-D-Val-L-Leu-D-Trp-)
• ETA-RECEPTOR ANTAGONIST
• cyclo(Trp-Asp-Pro-Val-Leu)
• BQ-123 >=99%, sodium salt, lyophilized powder
• D-TRP-D-ASP-PRO-D-VAL-LEU
• BQ-123;BQ 123;BQ123
• BQ-518
• Cyclo[D-Asp-L-Pro-D-Val-L-Leu-D-Trp-]
• BQ-123
• C(DTRP-DASP-PRO-DVAL-LEU)
• 2-((3R,6S,9R,12R,17aS)-9-((1H-indol-3-yl)methyl)-6-isobutyl-3-isopropyl-1,4,7,10,13-pentaoxohexadecahydro-1H-pyrrolo[1,2-a][1,4,7,10,13]pentaazacyclopentadecin-12-yl)acetic acid
• Cyclo(D-α-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl
• BQ-123 SYNTHETIC >99% SELECTIVE ETA ENDO THE
• PMZ 2123
• M.W. 610.70 C31H42N6O7
• Cyclo(D-α-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl)
• CYCLO (-D-TRP-D-ASP-PRO-D-VAL-LEU) SODIUM SALT
• 2-[(3R,6R,9S,12R,15S)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]acetic acid
• CYCLO(D-ASP-PRO-D-VAL-LEU-DTRP NA)

BQ-123

CAS: 136553-81-6

BQ-123 is a potent endothelin antagonist with high selectivity for the ET-A receptor subtype.

Formula: C₃₁H₄₂N₆O₇

Purity: 98.4%

Color and Shape: Yellow

Molecular weight: 610.71

Ref: 01-4016690

Cyclo(D-α-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl)

CAS: 136553-81-6

Formula: C₃₁H₄₂N₆O₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 610.7012

Ref: IN-DA009ARV

2-((3R,6S,9R,12R,17As)-9-((1H-Indol-3-Yl)Methyl)-6-Isobutyl-3-Isopropyl-1,4,7,10,13-Pentaoxohexadecahydro-1H-Pyrrolo[1,2-A][1,4,7,10,13]Pentaazacyclopentadecin-12-Yl)Acetic Acid

CAS: 136553-81-6

2-((3R,6S,9R,12R,17As)-9-((1H-Indol-3-Yl)Methyl)-6-Isobutyl-3-Isopropyl-1,4,7,10,13-Pentaoxohexadecahydro-1H-Pyrrolo[1,2-A][1,4,7,10,13]Pentaazacyclopentadecin-12-Yl)Acetic Acid

Purity: 98%

Molecular weight: 610.7g/mol

Ref: 54-OR1023197

BQ-123

CAS: 136553-81-6

BQ-123

Purity: ≥95%

Molecular weight: 610.7g/mol

Ref: 54-BUP08189

BQ-123

CAS: 136553-81-6

BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.

Formula: C₃₁H₄₂N₆O₇

Purity: 99.22% - ≥95%

Color and Shape: Solid

Molecular weight: 610.7

Ref: TM-T6792

BQ-123-d7

CAS: 136553-81-6

Formula: C₃₁H₃₅D₇N₆O₇

Molecular weight: 617.75

Ref: 4Z-PB-200002

BQ-123 [Cyclo(D-Trp-D-Asp-Pro-D-Val-Leu)]

CAS: 136553-81-6

Formula: C₃₁H₄₂N₆O₇

Molecular weight: 610.71

Ref: 4Z-PB-200001

BQ-123-13C6-15N

CAS: 136553-81-6

Formula: C₂₅₁₃C₆H₄₂N₅₁₅NO₇

Molecular weight: 617.66

Ref: 4Z-PB-200003

BQ-123 Sodium Salt

CAS: 136553-81-6

BQ-123 is a cyclic peptide that blocks the endothelin-A receptor. It has been shown to be an effective treatment for pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and other inflammatory conditions. BQ-123 binds to the endothelin-A receptor, which is located on the surface of cells in many tissues throughout the body. When bound, it inhibits intracellular calcium concentrations by reducing voltage-gated calcium channels and prevents the release of neurotransmitters. BQ-123 also has a stabilizing effect on hydrogen bonds due to its charged side chains. This property may account for its ability to form stable complexes with other proteins, inhibiting their function.
BQ-123 has been shown to have an active binding site on cyclic AMP response element binding protein (CREB) that inhibits CREB activity, thereby reducing protein synthesis. It also blocks cyclic GMP (cGMP)-dependent protein kin

Formula: C₃₁H₄₂N₆O₇

Purity: Min. 95%

Molecular weight: 610.70 g/mol

Ref: 3D-PED-3512-PI

BQ-123 Cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu)

CAS: 136553-81-6

BQ-123 is a cyclic peptide that has been shown to have a binding affinity for the serotonin receptor. The binding of BQ-123 to the receptor leads to a reduction in intracellular calcium concentration, which may be due to the inhibition of serine protease activity. This agent also inhibits the production of tumour necrosis factor-α (TNF-α) and has an inhibitory effect on cardiac contractility.

Formula: C₃₁H₄₂N₆O₇

Purity: Min. 95%

Molecular weight: 610.7 g/mol

Ref: 3D-FB108394