CAS 136572-09-3: Irinotecan hydrochloride trihydrate

Description: Irinotecan hydrochloride trihydrate is a chemotherapeutic agent primarily used in the treatment of colorectal cancer. It is a water-soluble salt derived from the natural alkaloid camptothecin and functions as a topoisomerase I inhibitor, disrupting DNA replication and transcription in cancer cells. The substance appears as a white to off-white crystalline powder and is hygroscopic, meaning it can absorb moisture from the environment. Its molecular formula includes a hydrochloride component and three water molecules, contributing to its stability and solubility in aqueous solutions. Irinotecan is administered intravenously and is often used in combination with other chemotherapeutic agents to enhance efficacy. Common side effects include diarrhea, nausea, and myelosuppression, necessitating careful monitoring during treatment. The compound's pharmacokinetics involve metabolism primarily by the liver, with active metabolites contributing to its therapeutic effects and toxicity. Overall, irinotecan hydrochloride trihydrate plays a significant role in oncology, particularly in managing advanced-stage cancers.

Formula: C₃₃H₃₈N₄O₆·ClH·3H₂O

InChI: InChI=1S/C33H38N4O6.ClH.3H2O/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;;;;/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;1H;3*1H2/t33-;;;;/m0..../s1

InChI key: InChIKey=KLEAIHJJLUAXIQ-JDRGBKBRSA-N

SMILES: Cl.O=C(OC=1C=CC2=NC=3C4=CC5=C(C(=O)N4CC3C(=C2C1)CC)COC(=O)C5(O)CC)N6CCC(N7CCCCC7)CC6.O

Synonyms:

• (+)-7-Ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin, monohydrochloride, trihydrate
• (+)-7-Ethyl-10-hydroxycamptothecine 10-(1,4'-bipiperidine)-1'-carboxylate, monohydrochloride, trihydrate
• (1,4'-Bipiperidine)-1'-Carboxylicacid,4,11-Diethyl-3,4,12,14-Tetrahydro-4-Hyd Monohydrochloride, Trihydrate
• (1,4'-Bipiperidine)-1'-carboxylic acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-9-yl ester, monohydrochloride, trihydrate, (S)-
• (19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl [1,4'-bipiperidine]-1'-carboxylate trihydrate hydrochloride
• (S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride trihydrate
• (S)-[1,4'-Bipiperidine]-1'-Carboxylic Acid 4,11-Diethyl-3,4,12,14-Tetrahydro-4-Hydroxy-3,14-Dioxo-1H-Pyrano
• (S)-[1,4'-Bipiperidine]-1'-carboxylic acid 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline, [1,4′-bipiperidine]-1′-carboxylic acid deriv.
• Camptosar
• Irinotecan HCl trihydrate
• Irinotecan Monohydrochloride Trihydrate
• Irinotecan hydrochloride hydrate
• Irinotecanhydrochloridetrihydrate(Cpt-11)
• Onivyde
• Onivyde pegylated liposomal
• Roxy-3,14-Dioxo-1H-Pyrano(3',4',6,7)Indolizino(1,2-B)Quinolin-9-Ylester,Mono
• Trihydrate,(S)-Hydrochlorid Trihydrate
• [1,4'-Bipiperidine]-1'-Carboxylic Acid (S)-4,11-Diethyl-3,4,12,14-Tetrahydro-4-Hydroxy-3,14-Dioxo-1H-Pyrano
• [1,4'-Bipiperidine]-1'-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester, hydrochloride, hydrate (1:1:3)
• [1,4′-Bipiperidine]-1′-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester, hydrochloride, hydrate (1:1:3)
• [1,4′-Bipiperidine]-1′-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester, monohydrochloride, trihydrate
• [1,4′-Bipiperidine]-1′-carboxylic acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester, monohydrochloride, trihydrate, (S)-
• [3',4',6,7]Indolizino[1,2-B]Quinolin-9-Yl Ester, Hcl Trihydrate
• [3',4':6,7]Indolizino[1,2-B]Quinolin-9-Yl Ester Hydrochloride Trihydrate

Irinotecan Hydrochloride Trihydrate

CAS: 100286-90-6 136572-09-397682-44-5

• Formula: C₃₃H₃₈N₄O₆·HCl·3H₂O
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Orange to Green powder to crystal
• Molecular weight: 677.20

Irinotecan hydrochloride trihydrate, 99%

CAS: 136572-09-3

Topoisomerase I inhibitor This Thermo Scientific Chemicals brand product was originally part of the Alfa …

• Formula: C₃₃H₄₅ClN₄O₉
• Purity: 99%
• Molecular weight: 677.19

Irinotecan for system suitability 2 CRS

CAS: 136572-09-3

• Formula: C₃₃H₃₈N₄O₆
• Color and Shape: Powder. Yellow. Light Yellow.
• Molecular weight: 586.678

Irinotecan for peak identification CRS

CAS: 136572-09-3

• Formula: C₃₃H₃₈N₄O₆
• Color and Shape: Powder. Yellow. Light Yellow.
• Molecular weight: 586.678

Irinotecan hydrochloride trihydrate CRS

CAS: 136572-09-3

• Formula: C₃₃H₃₈N₄O₆
• Color and Shape: Powder. Yellow. Light Yellow.
• Molecular weight: 586.678

Irinotecan for system suitability 1 CRS

CAS: 136572-09-3

Irinotecan Hydrochloride

CAS: 136572-09-3

Other alkaloids,natural or reproduced by synthesis, and their salts, ethers,esters&other derivatives, nesoi

• Formula: C₃₃H₃₈N₄O₆·HCl· 3H₂O
• Color and Shape: Pale Yellow Yellow Powder
• Molecular weight: 586.27913

Irinotecan hydrochloride trihydrate

CAS: 136572-09-3

• Formula: C₃₃H₄₅ClN₄O₉
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 677.1848

Irinotecan hydrochloride trihydrate

CAS: 136572-09-3

Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1.

• Formula: C₃₃H₄₅ClN₄O₉
• Purity: 98.22% - 99.79%
• Color and Shape: Pale Yellow To Yellow Crystalline Powder
• Molecular weight: 677.18

Irinotecan hydrochloride trihydrate

CAS: 136572-09-3

• Formula: C₃₃H₃₈N₄O₆·HCl· 3(H₂O)
• Purity: ≥ 99.0% (anhydrous)
• Color and Shape: Off-white to yellow crystalline powder
• Molecular weight: 623.14 (anhydrous)

Irinotecan Hydrochloride Trihydrate

CAS: 136572-09-3

• Purity: 98%
• Molecular weight: 677.18g/mol

Irinotecan Hydrochloride Trihydrate

CAS: 136572-09-3

• Formula: C₃₃H₃₈N₄O₆·ClHH₂O
• Color and Shape: Neat
• Molecular weight: 677.18

Irinotecan hydrochloride trihydrate

CAS: 136572-09-3

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Formula: C₃₃H₄₅ClN₄O₉
• Color and Shape: Powder, Yellow
• Molecular weight: 677.19

Irinotecan Hydrochloride Trihydrate

CAS: 136572-09-3

Applications Irinotecan Hydrochloride Trihydrate is a DNA topoisomerase inhibitor. References Kunimoto, T., et al.: Cancer …

• Formula: C₃₃H₃₈N₄O₆·ClHH₂O
• Color and Shape: Light Yellow
• Molecular weight: 677.18

Irinotecan, Hydrochloride Salt

CAS: 136572-09-3

• Purity: 98.0%
• Color and Shape: Solid
• Molecular weight: 623.1500244140625

Irinotecan hydrochloride trihydrate - Bio-X ™

CAS: 136572-09-3

Irinotecan hydrochloride trihydrate is a topoisomerase I inhibitor that is used as chemotherapy drug for …

• Formula: C₃₃H₃₈N₄O₆•HCl•(H₂O)₃
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 677.18 g/mol

Irinotecan hydrochloride trihydrate

CAS: 136572-09-3

Inhibitor of DNA topoisomerase I

• Formula: C₃₃H₃₈N₄O₆•HCl•(H₂O)₃
• Purity: Min. 97 Area-%
• Color and Shape: Yellow Powder
• Molecular weight: 677.18 g/mol

(R)-Irinotecan Hydrochloride-d10 Trihydrate

CAS: 1255644-71-3 136572-09-3

• Formula: C₃₃H₃₅D₁₀ClN₄O₉
• Color and Shape: Neat
• Molecular weight: 687.25

(R)-Irinotecan Hydrochloride Trihydrate

CAS: 1255644-71-3 136572-09-31992961-26-8

• Formula: C₃₃H₃₈N₄O₆·HCl· 3H₂O
• Color and Shape: Neat
• Molecular weight: 677.21