CAS 136656-07-0

Timosaponin B II

Description:

Timosaponin B II is a saponin compound primarily derived from the plant species Timosaponin, which is known for its various biological activities. It is characterized by its complex glycosidic structure, which typically includes a steroid or triterpenoid aglycone linked to one or more sugar moieties. This structural configuration contributes to its surfactant properties, allowing it to interact with biological membranes. Timosaponin B II has been studied for its potential pharmacological effects, including anti-inflammatory, anti-cancer, and immunomodulatory activities. Additionally, it may exhibit cytotoxic effects against certain cancer cell lines, making it a subject of interest in medicinal chemistry. The compound is soluble in organic solvents and may have limited solubility in water, which is common for many saponins. Its safety profile and potential therapeutic applications continue to be explored in scientific research, highlighting the importance of natural products in drug discovery and development.

Formula: C₄₅H₇₆O₁₉

InChI: InChI=1/C45H76O19/c1-19(18-58-40-37(55)34(52)31(49)27(15-46)60-40)7-12-45(57)20(2)30-26(64-45)14-25-23-6-5-21-13-22(8-10-43(21,3)24(23)9-11-44(25,30)4)59-42-39(36(54)33(51)29(17-48)62-42)63-41-38(56)35(53)32(50)28(16-47)61-41/h19-42,46-57H,5-18H2,1-4H3/t19-,20-,21+,22-,23+,24-,25-,26-,27+,28+,29+,30-,31+,32+,33-,34-,35-,36-,37+,38+,39+,40+,41-,42+,43-,44-,45?/m0/s1

InChI key: InChIKey=SORUXVRKWOHYEO-UJDJZYEZSA-N

SMILES: C[C@@]12[C@]([C@]3([C@](CC1)([C@]4(C)[C@](CC3)(C[C@@H](O[C@H]5[C@H](O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)[C@@H](O)[C@@H](O)[C@@H](CO)O5)CC4)[H])[H])[H])(C[C@]7([C@@]2([C@H](C)[C@](CC[C@@H](CO[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)C)(O)O7)[H])[H])[H]

Synonyms:

• (3β,5β,22α,25S)-26-(β-<span class="text-smallcaps">D</smallcap>-Glucopyranosyloxy)-22-hydroxyfurostan-3-yl 2-O-β-<smallcap>D</smallcap>-glucopyranosyl-β-<smallcap>D</span>-galactopyranoside
• 1H-Naphth[2′,1′:4,5]indeno[2,1-b]furan, β-<span class="text-smallcaps">D</span>-galactopyranoside deriv.
• 25S-Timosaponin B II
• Furostan, β-<span class="text-smallcaps">D</span>-galactopyranoside deriv.
• Prototimosaponin A III
• Timosaponin B2
• Timosaponin Bii
• β-<span class="text-smallcaps">D</smallcap>-Galactopyranoside, (3β,5β,22α,25S)-26-(β-<smallcap>D</smallcap>-glucopyranosyloxy)-22-hydroxyfurostan-3-yl 2-O-β-<smallcap>D</span>-glucopyranosyl-
• 1H-Naphth[2′,1′:4,5]indeno[2,1-b]furan, β-D-galactopyranoside deriv.
• (3β,5β,22α,25S)-26-(β-D-Glucopyranosyloxy)-22-hydroxyfurostan-3-yl 2-O-β-D-glucopyranosyl-β-D-galactopyranoside
• β-D-Galactopyranoside, (3β,5β,22α,25S)-26-(β-D-glucopyranosyloxy)-22-hydroxyfurostan-3-yl 2-O-β-D-glucopyranosyl-
• Furostan, β-D-galactopyranoside deriv.
• timosaponin B-II
• Anemarsaponin BII, 98%, from Anemarrhena asphodeloides Bunge
• Timosaponin BII USP/EP/BP
• (25S)-26-(β-D-Glucopyranosyloxy)-3β-[(2-O-β-D-glucopyranosyl-β-D-galactopyranosyl)oxy]-5β-furostan-22-ol
• (25S)-3β-[(2-O-β-D-Glucopyranosyl-β-D-galactopyranosyl)oxy]-26-(β-D-glucopyranosyloxy)-5β-furostane-22-ol

β-D-Galactopyranoside, (3β,5β,22α,25S)-26-(β-D-glucopyranosyloxy)-22-hydroxyfurostan-3-yl 2-O-β-D-glucopyranosyl-

CAS: 136656-07-0

Formula: C₄₅H₇₆O₁₉

Purity: 95%

Color and Shape: Solid

Molecular weight: 921.0735

Ref: IN-DA00126J

Timosaponin BII

CAS: 136656-07-0

Timosaponin BII

Purity: ≥98%

Molecular weight: 921.07g/mol

Ref: 54-BUP07152

Timosaponin BII

CAS: 136656-07-0

Formula: C₄₅H₇₆O₁₉

Molecular weight: 921.08

Ref: 7W-GY6130

Timosaponin BII

CAS: 136656-07-0

Timosaponin BII has anti-diabetes, antioxidant, anti-inflammatory, and anti-dementia activities, it can significantly reduce the neurotoxicity induced by beta amyloid peptide 25-35 in primary neurons, the mechanism of which may be related with resisting oxidative damage and regulating the cholinergic system.Timosaponin BII can improve the neurological symptoms of cerebral ischemic rat, reduce infarct size, relieve brain water edema, improve hemorheology, reduce inflammatory injury of cerebral ischemia; it could be used in the preparation of a medicament or product for the prevention and treatment of stroke.

Formula: C₄₅H₇₆O₁₉

Purity: 95%~99%

Molecular weight: 921.084

Ref: BP-BP1396

Timosaponin BII

CAS: 136656-07-0

Timosaponin BII combats dementia, treats type 2 diabetes, has antioxidant properties, and reduces BACE1 with retinal benefits.

Formula: C₄₅H₇₆O₁₉

Purity: 98% - >99.99%

Color and Shape: Solid

Molecular weight: 921.07

Ref: TM-T3394

Timosaponin b ii

CAS: 136656-07-0

Natural glycoside

Formula: C₄₅H₇₆O₁₉

Purity: ≥ 98.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 921.09

Ref: 5G-83272

Timosaponin B II

CAS: 136656-07-0

Timosaponin B II is a natural compound that inhibits the activity of cytochrome P450 enzymes. It has been shown to induce autophagy in a dopamine-dependent manner, which may be due to its ability to decrease mitochondrial membrane potential and increase phase transition temperature. Timosaponin B II also induces neurotrophic factors and matrix effects, which are beneficial for the treatment of inflammatory conditions, neurodegenerative diseases, and metabolic disorders. The drug has been shown to have pharmacokinetic properties that are similar to those of timosaponin I. The molecular weight of the molecule was determined by LC-MS/MS analysis as 527.2 amu. Timosaponin B II is not metabolized by cytochrome P450 enzymes or glucuronidases, but it is hydrolyzed by esterases or glutathione reductase.

Formula: C₄₅H₇₆O₁₉

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 921.07 g/mol

Ref: 3D-FT73829