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CAS 136675-87-1

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3',5'-Bis-O-benzoyl-2'-Deoxy-2'-fluoro-4-deoxy-arabinouridine

Description:
3',5'-Bis-O-benzoyl-2'-deoxy-2'-fluoro-4-deoxy-arabinouridine is a modified nucleoside that exhibits unique structural and chemical characteristics. This compound features a deoxy sugar moiety with a fluorine substitution at the 2' position, which can influence its biological activity and stability. The presence of two benzoyl groups at the 3' and 5' positions enhances its lipophilicity and may improve cellular uptake. This nucleoside is of interest in medicinal chemistry and biochemistry, particularly in the development of antiviral and anticancer agents, as modifications to nucleosides can alter their interaction with nucleic acids and enzymes. The fluorine atom can also impart resistance to enzymatic degradation, making it a valuable candidate for therapeutic applications. Additionally, the compound's structural modifications can affect its binding affinity to targets such as polymerases or other nucleic acid-related enzymes, potentially leading to novel mechanisms of action. Overall, 3',5'-Bis-O-benzoyl-2'-deoxy-2'-fluoro-4-deoxy-arabinouridine represents a significant area of research in the field of nucleoside analogs.
Formula:C23H19FN2O6
Synonyms:
  • 3',5'-Bis-O-benzoyl-2'-Deoxy-2'-fluoro-4-deoxy-arabinouridine
  • 2(1H)-Pyrimidinone, 1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-
  • 1-(2'-deoxy-2'-fluoro-3',5'-dibenzoyl-D-arabinofuranosyl)pyrimidin-2(1H)-one
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