CAS 136816-76-7

Delavuridine

Description:

Delavuridine, also known by its developmental code name, is a nucleoside reverse transcriptase inhibitor (NRTI) primarily studied for its potential use in the treatment of HIV/AIDS. It is characterized by its ability to interfere with the reverse transcription process of the viral life cycle, thereby inhibiting viral replication. Delavuridine is structurally related to other nucleoside analogs, featuring a modified sugar moiety that enhances its antiviral activity. The compound is typically administered orally and has been evaluated for its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion. While it has shown promise in clinical trials, its use has been limited due to the development of resistance and the availability of more effective antiretroviral therapies. Delavuridine's safety profile includes potential side effects common to NRTIs, such as gastrointestinal disturbances and effects on mitochondrial function. Overall, while delavuridine represents an important class of antiviral agents, its clinical application has been overshadowed by newer, more effective treatments.

Formula: C₂₁H₂₅N₅O

InChI: InChI=1S/C21H25N5O/c1-15(2)23-18-8-5-9-22-20(18)25-10-12-26(13-11-25)21(27)19-14-16-6-3-4-7-17(16)24-19/h3-9,14-15,23-24H,10-13H2,1-2H3

InChI key: InChIKey=ASOMNDIOOKDVDC-UHFFFAOYSA-N

SMILES: N(C(C)C)C1=C(N=CC=C1)N2CCN(C(=O)C3=CC=4C(N3)=CC=CC4)CC2

Synonyms:

• Piperazine, 1-(1H-indol-2-ylcarbonyl)-4-[3-[(1-methylethyl)amino]-2-pyridinyl]-
• Methanone, 1H-indol-2-yl[4-[3-[(1-methylethyl)amino]-2-pyridinyl]-1-piperazinyl]-
• 1H-Indol-2-yl[4-[3-[(1-methylethyl)amino]-2-pyridinyl]-1-piperazinyl]methanone
• U 88204
• BHAP

U 88204

CAS: 136816-76-7

U 88204 is a non-nucleoside HIV-1 reverse transcriptase inhibitor.

Formula: C₂₁H₂₅N₅O

Color and Shape: Solid

Molecular weight: 363.46

Ref: TM-T70851