CAS 136817-59-9

Delavirdine

Description:

Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) primarily used in the treatment of HIV infection. It functions by binding to the reverse transcriptase enzyme, thereby inhibiting the conversion of viral RNA into DNA, which is a crucial step in the HIV replication cycle. Delavirdine is characterized by its chemical structure, which includes a pyrimidine ring and a phenyl group, contributing to its pharmacological activity. It is typically administered orally and has a relatively short half-life, necessitating multiple daily doses for effective viral suppression. The substance is known for its potential drug interactions, particularly with other antiretroviral medications and certain medications metabolized by the liver. Common side effects may include rash, gastrointestinal disturbances, and fatigue. Due to the emergence of resistance, delavirdine is often used in combination with other antiretroviral agents to enhance efficacy and reduce the likelihood of viral resistance. Overall, delavirdine plays a role in the broader context of HIV treatment regimens, although its use has declined with the advent of newer NNRTIs and integrase inhibitors.

Formula: C₂₂H₂₈N₆O₃S

InChI: InChI=1/C22H28N6O3S/c1-15(2)24-19-5-4-8-23-21(19)27-9-11-28(12-10-27)22(29)20-14-16-13-17(26-32(3,30)31)6-7-18(16)25-20/h4-8,13-15,24-26H,9-12H2,1-3H3

InChI key: InChIKey=WHBIGIKBNXZKFE-UHFFFAOYSA-N

SMILES: N(C(C)C)C1=C(N=CC=C1)N2CCN(C(=O)C3=CC=4C(N3)=CC=C(NS(C)(=O)=O)C4)CC2

Synonyms:

• 1-(3-((1-Methylethyl)amino)-2-pyridinyl)-4-((5-((methylsulfonyl)amino)-1H-indol-2-yl)carbonyl)piperazine
• 1-[3-(Isopropylamino)-2-pyridyl]-4-[(5-methanesulfonamidoindol-2-yl)carbonyl]piperazine
• 2-(4-(5-Methanesulfonamido-1H-indol-2-ylcarbonyl)-1-piperazinyl)-N-(1-methylethyl)-3-pyridinamine
• Bhap-U 90152
• Delavirdine [INN]
• Methanesulfonamide, N-[2-[[4-[3-[(1-methylethyl)amino]-2-pyridinyl]-1-piperazinyl]carbonyl]-1H-indol-5-yl]-
• N-[2-({4-[3-(propan-2-ylamino)pyridin-2-yl]piperazin-1-yl}carbonyl)-1H-indol-5-yl]methanesulfonamide
• N-[2-[[4-[3-[(1-Methylethyl)amino]-2-pyridinyl]-1-piperazinyl]carbonyl]-1H-indol-5-yl]methanesulfonamide
• Piperazine, 1-(3-((1-methylethyl)amino)-2-pyridinyl)-4-((5-((methylsulfonyl)amino)-1H-indol-2-yl)carbonyl)-
• U 90152
• Unii-Dol5F9Jd3E
• Delavirdine & Delavirdine Mesylate
• 147221-93-0 (Mesylate)
• DELAVIRDINE
• N-(2-(4-(3-(IsopropylaMino)pyridin-2-yl)piperazine-1-carbonyl)-1H-indol-5-yl)MethanesulfonaMide

N-(2-(4-(3-(Isopropylamino)pyridin-2-yl)piperazine-1-carbonyl)-1H-indol-5-yl)methanesulfonamide

CAS: 136817-59-9

N-(2-(4-(3-(Isopropylamino)pyridin-2-yl)piperazine-1-carbonyl)-1H-indol-5-yl)methanesulfonamide

Purity: 99%

Molecular weight: 456.57g/mol

Ref: 54-OR1065251

Delavirdine

CAS: 136817-59-9

Formula: C₂₂H₂₈N₆O₃S

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 456.56

Ref: 7W-GP3886

Delavirdine

CAS: 136817-59-9

Delavirdine, an NNRTI for HIV-1, is used in HAART.

Formula: C₂₂H₂₈N₆O₃S

Color and Shape: Solid

Molecular weight: 456.56

Ref: TM-T7212L

Delavirdine

Controlled Product

CAS: 136817-59-9

Applications A bisheteroarylpiperazine (BHAP) reverse transcriptase inhibitor.
References Dueweke, T.J., et al.: Antimicrob. Ag. Chemother., 37, 1127 (1993), Althaus, I.W., et al.: Biochem. Pharmacol., 47, 2017 (1994)

Formula: C₂₂H₂₈N₆O₃S

Color and Shape: Neat

Molecular weight: 456.56

Ref: TR-D230625