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CAS 136832-63-8

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5-Chloromethylfluorescein diacetate

Description:
5-Chloromethylfluorescein diacetate (CAS 136832-63-8) is a fluorescent dye commonly used in biological and chemical research, particularly for cell labeling and tracking. This compound is a derivative of fluorescein, characterized by the presence of a chloromethyl group and two acetate groups, which enhance its lipophilicity and facilitate cellular uptake. Upon entering cells, the diacetate groups are hydrolyzed by intracellular esterases, releasing the fluorescent fluorescein moiety, which can then be detected using fluorescence microscopy or flow cytometry. The chloromethyl group allows for covalent bonding to cellular components, making it useful for studying cellular processes and dynamics. The compound exhibits strong fluorescence properties, typically in the green spectrum, and is sensitive to pH changes and environmental conditions. Its applications extend to various fields, including cell biology, pharmacology, and toxicology, where it aids in visualizing cellular structures and functions. Safety precautions should be observed when handling this compound, as with many fluorescent dyes, due to potential toxicity and environmental concerns.
Formula:C25H17ClO7
InChI:InChI=1S/C25H17ClO7/c1-13(27)30-16-4-7-20-22(10-16)32-23-11-17(31-14(2)28)5-8-21(23)25(20)19-6-3-15(12-26)9-18(19)24(29)33-25/h3-11H,12H2,1-2H3
InChI key:InChIKey=IPJDHSYCSQAODE-UHFFFAOYSA-N
SMILES:O=C1OC2(C=3C1=CC(CCl)=CC3)C=4C(OC=5C2=CC=C(OC(C)=O)C5)=CC(OC(C)=O)=CC4
Synonyms:
  • 3′,6′-Bis(acetyloxy)-5-(chloromethyl)spiro[isobenzofuran-1(3H),9′-[9H]xanthen]-3-one
  • 5-(And-6)-Chloromethyl Snarf(R)-1, Acetate
  • 5-(chloromethyl)-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-3',6'-diyl diacetate
  • 5-Chloromethylfluorescein
  • CellTracker Green CMFDA
  • Celltracker(Tm) Green Cmfda
  • Cmfda
  • Green Cmfda
  • Spiro[isobenzofuran-1(3H),9′-[9H]xanthen]-3-one, 3′,6′-bis(acetyloxy)-5-(chloromethyl)-
  • 5-Chloromethylfluorescein diacetate
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