CAS 1369773-39-6

[1,1′-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, 4-ethyl ester, calcium salt (2:1), (αR,γS)-

Description:

The chemical substance known as "[1,1′-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, 4-ethyl ester, calcium salt (2:1), (αR,γS)-" with CAS number 1369773-39-6 is a complex organic compound characterized by its biphenyl structure, which consists of two phenyl rings connected by a single bond. This compound features a pentanoic acid moiety, indicating the presence of a five-carbon carboxylic acid chain, and an amino group that contributes to its potential biological activity. The presence of an ester functional group suggests that it may exhibit properties typical of esters, such as volatility and solubility in organic solvents. The calcium salt form indicates that it is likely to be used in applications where calcium ions play a role, possibly in biological systems or as a supplement. The stereochemistry, denoted by (αR,γS), implies specific spatial arrangements of atoms, which can influence the compound's reactivity and interaction with biological targets. Overall, this substance may have applications in pharmaceuticals or biochemistry, particularly in the context of drug design or as a biochemical probe.

Formula: C₂₄H₂₉NO₅Ca

InChI: InChI=1S/C24H29NO5.Ca/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19;/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28);/t17-,21+;/m1./s1

InChI key: InChIKey=SLERTBUHPREHKD-JKSHRDEXSA-N

SMILES: C([C@H](C[C@H](C(OCC)=O)C)NC(CCC(O)=O)=O)C1=CC=C(C=C1)C2=CC=CC=C2.[Ca]

Synonyms:

• (alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt
• (αR,γS)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt
• AHU-377 hemicalcium salt
• AHU377 Calcium salt
• Sacubitril Hemicalcium
• Sacubitril Hemicalcium salt
• [1,1′-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, 4-ethyl ester, calcium salt (2:1), (αR,γS)-
• Sacubitril Calcium
• SacubitrilValsartan Sodium
• (alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl) amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1)

[1,1'-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, 4-ethyl ester, calcium salt (2:1), (αR,γS)-

CAS: 1369773-39-6

Formula: C₄₈H₅₆CaN₂O₁₀

Purity: 98%

Color and Shape: Solid

Molecular weight: 861.0436

Ref: IN-DA0012M5

Sacubitril hemicalcium salt

CAS: 1369773-39-6

Sacubitril hemicalcium salt

Purity: ≥98%

Molecular weight: 861.06g/mol

Ref: 54-BUP13083

Sacubitril Calcium

CAS: 1369773-39-6

Sacubitril Calcium

Purity: 99%

Molecular weight: 861.04g/mol

Ref: 54-IN12011

Sacubitril hemicalcium salt

CAS: 1369773-39-6

Sacubitril hemicalcium salt (AHU377 calcium salt) is a potent NEP inhibitor with an IC50 of 5 nM.

Formula: C₄₈H₅₆CaN₂O₁₀

Purity: 99.86% - 99.93%

Color and Shape: Solid

Molecular weight: 861.06

Ref: TM-T4200

Sacubitril Calcium

CAS: 1369773-39-6

Applications Sacubitril is an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.
References McMurray, J., et al.: N. Eng. J. Med., 371 (2014)

Formula: C₂₄H₂₈NOCa₂

Color and Shape: Neat

Molecular weight: 430.52

Ref: TR-S080900

Sacubitril calcium

CAS: 1369773-39-6

Inhibitor of metalloendopeptidase neprilysin

Formula: C₂₄H₂₉NO₅•Ca₀

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 431.53 g/mol

Ref: 3D-FH139149

4-(((2S,4R)-1-([1,1′-BIPHENYL]-4-YL)-5-ETHOXY-4-METHYLPENTAN-2-YL)AMINO)-4-OXOBUTANOIC ACID

CAS: 1369773-39-6

Formula: C₂₄H₃₁NO₄

Purity: 95.0%

Molecular weight: 397.515

Ref: 10-F470019