CAS 1369852-71-0

Lotilaner

Description:

Lotilaner is a novel isoxazoline compound primarily used as an antiparasitic agent, particularly in veterinary medicine for the treatment of fleas and ticks in dogs. It operates by inhibiting the function of certain neurotransmitter receptors in parasites, leading to their paralysis and death. Lotilaner is characterized by its high efficacy, rapid onset of action, and prolonged duration of effect, making it a popular choice for pet owners seeking effective parasite control. The compound is administered orally and is well-absorbed, with a favorable safety profile for dogs. Its chemical structure includes a unique isoxazoline ring, which is crucial for its biological activity. Lotilaner is also noted for its low toxicity to mammals, which allows for safe use in companion animals. Additionally, it has been studied for its potential use in other veterinary applications, reflecting its versatility as an antiparasitic agent. Overall, Lotilaner represents a significant advancement in the field of veterinary pharmacology, providing effective protection against common ectoparasites.

Formula: C₂₀H₁₄Cl₃F₆N₃O₃S

InChI: InChI=1S/C20H14Cl3F6N3O3S/c1-8-2-13(36-16(8)17(34)30-6-14(33)31-7-19(24,25)26)12-5-18(35-32-12,20(27,28)29)9-3-10(21)15(23)11(22)4-9/h2-4H,5-7H2,1H3,(H,30,34)(H,31,33)/t18-/m0/s1

InChI key: InChIKey=HDKWFBCPLKNOCK-SFHVURJKSA-N

SMILES: [C@](F)(F)(F)[C@]1(CC(=NO1)C=2SC(C(NCC(NCC(F)(F)F)=O)=O)=C(C)C2)C3=CC(Cl)=C(Cl)C(Cl)=C3

Synonyms:

• Xdemvy
• 5-[(5S)-4,5-Dihydro-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-3-isoxazolyl]-3-methyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-2-thiophenecarboxamide
• Credelio
• Lotilaner
• (S)-5-[5-(3,4,5-trichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-3-methyl-thiophene-2-carboxylic acid [(2,2,2-trifluoro-ethylcarbamoyl)-methyl]-amide
• 2-Thiophenecarboxamide, 5-[(5S)-4,5-dihydro-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-3-isoxazolyl]-3-methyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-

(S)-5-[5-(3,4,5-Trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-3-methylthiophene-2-carboxylic acid [(2,2,2-trifluoroethyl carbamoyl) methyl] amide

CAS: 1369852-71-0

Formula: C₂₀H₁₄Cl₃F₆N₃O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 596.7579

Ref: IN-DA01KZ72

Lotilaner

CAS: 1369852-71-0

Lotilaner is a parasiticide.

Formula: C₂₀H₁₄Cl₃F₆N₃O₃S

Purity: 99.56%

Color and Shape: Solid

Molecular weight: 596.76

Ref: TM-T15775

Lotilaner

CAS: 1369852-71-0

Formula: C₂₀H₁₄Cl₃F₆N₃O₃S

Molecular weight: 596.75

Ref: 4Z-L-230001

Lotilaner

CAS: 1369852-71-0

Lotilaner

Purity: ≥98%

Molecular weight: 596.76g/mol

Ref: 54-BUP08641

Lotilaner

CAS: 1369852-71-0

Formula: C₂₀H₁₄Cl₃F₆N₃O₃S

Color and Shape: Neat

Molecular weight: 596.76

Ref: 04-C14648200

Lotilaner

CAS: 1369852-71-0

Lotilaner is a new chemical pesticide that belongs to the family of pyrazolines. It is a prodrug that is activated by esterases in the insect gut and by phosphatases in the red blood cells. Activation leads to inhibition of chitin synthase, which is required for chitin synthesis, leading to cell death. Lotilaner has been shown to be active against molluscs and insects. The drug also has a long terminal half-life and high elimination rate, which makes it suitable for use as a control agent. Clinical studies have demonstrated its efficacy against bacterial strains such as Pseudomonas aeruginosa, Escherichia coli, Enterococcus faecalis, Staphylococcus aureus and Salmonella enterica serovar Typhi. It has also been shown to be effective in clinical pathology models of infection with these pathogens. Lotilaner has pharmacokinetic properties that are similar to those of

Formula: C₂₀H₁₄Cl₃F₆N₃O₃S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 596.8 g/mol

Ref: 3D-UEC85271

Lotilaner

Controlled Product

CAS: 1369852-71-0

Formula: C₂₀H₁₄Cl₃F₆N₃O₃S

Color and Shape: Neat

Molecular weight: 596.76

Ref: TR-L470620