CAS 1370468-36-2

Elbasvir

Description:

Elbasvir is an antiviral medication primarily used in the treatment of hepatitis C virus (HCV) infections. It functions as an NS5A inhibitor, targeting a specific protein essential for viral replication and assembly. Elbasvir is often combined with other antiviral agents to enhance its efficacy and broaden the treatment spectrum against various HCV genotypes. The substance is characterized by its high potency and selectivity for the NS5A protein, which contributes to its effectiveness in suppressing viral load. In terms of chemical properties, Elbasvir has a complex molecular structure that includes multiple functional groups, contributing to its pharmacological activity. It is typically administered orally and is well-absorbed in the gastrointestinal tract. The drug's safety profile is generally favorable, with common side effects including fatigue and headache, but it is crucial to monitor for potential drug interactions, especially when used in combination therapies. Overall, Elbasvir represents a significant advancement in the management of hepatitis C, offering patients a more effective treatment option.

Formula: C₄₉H₅₅N₉O₇

InChI: InChI=1S/C49H55N9O7/c1-27(2)41(54-48(61)63-5)45(59)56-20-10-14-37(56)43-50-25-34(52-43)30-17-19-36-32(22-30)23-39-33-18-16-31(24-40(33)65-47(58(36)39)29-12-8-7-9-13-29)35-26-51-44(53-35)38-15-11-21-57(38)46(60)42(28(3)4)55-49(62)64-6/h7-9,12-13,16-19,22-28,37-38,41-42,47H,10-11,14-15,20-21H2,1-6H3,(H,50,52)(H,51,53)(H,54,61)(H,55,62)/t37-,38-,41-,42-,47-/m0/s1

InChI key: InChIKey=BVAZQCUMNICBAQ-PZHYSIFUSA-N

SMILES: C([C@@H](NC(OC)=O)C(C)C)(=O)N1[C@H](C=2NC(C=3C=C4C(N5C(C=6C(O[C@H]5C7=CC=CC=C7)=CC(=CC6)C=8NC(=NC8)[C@H]9N(C([C@@H](NC(OC)=O)C(C)C)=O)CCC9)=C4)=CC3)=CN2)CCC1

Synonyms:

• Carbamic acid, N,N′-[[(6S)-6-phenyl-6H-indolo[1,2-c][1,3]benzoxazine-3,10-diyl]bis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis-, C,C′-dimethyl ester
• Elbasvir
• MK 8742

Carbamic acid, N,N'-[[(6S)-6-phenyl-6H-indolo[1,2-c][1,3]benzoxazine-3,10-diyl]bis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis-, C,C'-dimethyl ester

CAS: 1370468-36-2

Formula: C₄₉H₅₅N₉O₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 882.0171

Ref: IN-DA0012RD

Elbasvir

CAS: 1370468-36-2

Elbasvir

Purity: ≥98%

Molecular weight: 882.02g/mol

Ref: 54-BUP09577

Dimethyl ((2S,2’S)-((2S,2’S)-2,2’-(5,5’-((S)-6-Phenyl-6H-Benzo[5,6][1,3]Oxazino[3,4-A]Indole-3,10-Diyl)Bis(1H-Imidazole-5,2-Diyl))Bis(Pyrrolidine-2,1-Diyl))Bis(3-Methyl-1-Oxobutane-2,1-Diyl))Dicarbama

CAS: 1370468-36-2

Dimethyl ((2S,2’S)-((2S,2’S)-2,2’-(5,5’-((S)-6-Phenyl-6H-Benzo[5,6][1,3]Oxazino[3,4-A]Indole-3,10-Diyl)Bis(1H-Imidazole-5,2-Diyl))Bis(Pyrrolidine-2,1-Diyl))Bis(3-Methyl-1-Oxobutane-2,1-Diyl))Dicarbama

Purity: 98%

Molecular weight: 882.02g/mol

Ref: 54-OR1023013

Elbasvir

CAS: 1370468-36-2

Elbasvir (MK-8742) is an NS5A inhibitor developed for chronic HCV treatment.

Formula: C₄₉H₅₅N₉O₇

Purity: 98.95% - 99.85%

Color and Shape: Solid

Molecular weight: 882.02

Ref: TM-T4544

Elbasvir

CAS: 1370468-36-2

Ref: 7W-GW9811

Elbasvir

CAS: 1370468-36-2

Formula: C₄₉H₅₅N₉O₇

Molecular weight: 882.04

Ref: 4Z-E-207001

Elbasvir

CAS: 1370468-36-2

Anti-viral; NS5A protein inhibitor

Formula: C₄₉H₅₅N₉O₇

Purity: Min. 95%

Color and Shape: White To Yellow Solid

Molecular weight: 881.42245

Ref: 3D-FD139291

Elbasvir

CAS: 1370468-36-2

Applications Elbasvir is a pharmaceutical drug that is used in the treatment of hepatitis C virus in patients with HCV genotype 1 infection. It inhibits an important viral phosphoprotein, NS5A, which is involved in viral replication, assembly, and secretion.
References Feld, J.J., et al.: New Eng. J. Med., 370, 1594 (2014); Lawitz, E., et al.: J. Hepatol., 57, 24 (2012); Afdhal, N., et al.: New England J. Med., 370, 1889 (2014)

Formula: C₄₉H₅₅N₉O₇

Color and Shape: Neat

Molecular weight: 882.017

Ref: TR-E501010