CAS 137056-72-5

(3beta)-cholest-5-en-3-yl [2-(dimethylamino)ethyl]carbamate

Description:

(3beta)-cholest-5-en-3-yl [2-(dimethylamino)ethyl]carbamate is a chemical compound that belongs to the class of cholesteryl derivatives. It features a cholestene backbone, characterized by a steroid structure with a double bond at the 5-position and a hydroxyl group at the 3-position. The compound is modified with a carbamate functional group, which is formed by the reaction of an amine (in this case, 2-(dimethylamino)ethyl) with a carbonyl compound. This modification enhances its solubility and bioavailability. The presence of the dimethylamino group suggests potential interactions with biological systems, possibly influencing its pharmacological properties. The compound may exhibit lipophilic characteristics due to its steroidal structure, which can affect its distribution in biological membranes. Overall, (3beta)-cholest-5-en-3-yl [2-(dimethylamino)ethyl]carbamate is of interest in medicinal chemistry and pharmacology, particularly for its potential applications in drug delivery systems or as a therapeutic agent.

Formula: C₃₂H₅₆N₂O₂

InChI: InChI=1/C32H56N2O2/c1-22(2)9-8-10-23(3)27-13-14-28-26-12-11-24-21-25(36-30(35)33-19-20-34(6)7)15-17-31(24,4)29(26)16-18-32(27,28)5/h11,22-23,25-29H,8-10,12-21H2,1-7H3,(H,33,35)/t23-,25+,26+,27-,28+,29+,31+,32-/m1/s1

3β[N-(N’,N’-Dimethylaminoethane)-carbamoyl]cholesterol

CAS: 137056-72-5

Liposome Reagent: Small liposomes could be easily prepared with mixtures of DC-Chol and 1,2-dioleoyl-sn-glycero-3-phosphorylethanolamine by sonification. These liposomes are very efficient in mediating the transfection of pUCSV2CAT plasmid DNA into four different types of cultured mammalian cells.

Formula: C₃₂H₅₆N₂O₂

Purity: > 99%

Color and Shape: White Powder

Molecular weight: 500.81

Ref: 01-4026174

3β-[N-(N',N'-Dimethylaminoethane)-carbamoyl]cholesterol

CAS: 137056-72-5

Formula: C₃₂H₅₆N₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 500.7992

Ref: IN-DA0012SG

3-β-[N-(N',N'-Dimethylaminoethane)-carbamoyl]cholesterol

Controlled Product

CAS: 137056-72-5

3-b-[N-(N',N'-Dimethylaminoethane)-carbamoyl]cholesterol (3BC) is a growth factor with immunomodulatory properties. It has been shown to inhibit the growth of mouse tumor cells by inhibiting the activity of acid complex, which is involved in the synthesis of DNA and RNA. 3BC also has an effect on cancer cells, as it stimulates epidermal growth factor receptors, leading to cell division arrest and programmed cell death. 3BC has been used for gene therapy to treat cancer and infectious diseases. The drug was administered in liposomes to enhance its stability and reduce side-effects.

Formula: C₃₂H₅₆N₂O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 500.8 g/mol

Ref: 3D-FB29764

3-β-[N-(N’,N’-Dimethylaminoethane)-carbamoyl]cholesterol

Controlled Product

CAS: 137056-72-5

Applications 3-β-[N-(N’,N’-Dimethylaminoethane)-carbamoyl]cholesterol is a cationic liposome reagent. It has been investigated in cancer gene therapy and vaccine delivery system.
References Goyal, K., et al.: J. Liposome Res., 5, 49 (1995); Christensen, D., et al.: Exp. Rev. Vac., 10, 513 (2011); Gao, X., et al.: Biochem. Biophys. Res. Comm., 179, 280 (1991)

Formula: C₃₂H₅₆N₂O₂

Color and Shape: Neat

Molecular weight: 500.8

Ref: TR-D470585