CAS 137071-32-0

Pimecrolimus

Description:

Pimecrolimus is a topical immunomodulator primarily used in the treatment of atopic dermatitis. It belongs to the class of drugs known as calcineurin inhibitors, which function by inhibiting T-cell activation and reducing the inflammatory response in the skin. The chemical formula of pimecrolimus reflects its complex structure, which includes a macrolactam ring. It is typically formulated as a cream for external application, allowing for localized treatment with minimal systemic absorption. Pimecrolimus is characterized by its ability to alleviate symptoms such as itching and inflammation without the side effects commonly associated with corticosteroids. Its mechanism of action involves the inhibition of pro-inflammatory cytokines, thereby modulating the immune response. The substance is generally well-tolerated, though some patients may experience local skin reactions. As with any medication, it is essential to use pimecrolimus under the guidance of a healthcare professional to ensure appropriate use and to monitor for any potential adverse effects.

Formula: C₄₃H₆₈ClNO₁₁

InChI: InChI=1/C43H68ClNO11/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)45-16-12-11-13-32(45)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-31(44)35(22-29)52-7/h18,20,25,27-33,35-39,46,51H,10-17,19,21-23H2,1-9H3/b24-18+,26-20+/t25-,27+,28-,29-,30+,31-,32-,33-,35+,36-,37-,38+,39+,43+/m0/s1

InChI key: InChIKey=KASDHRXLYQOAKZ-XDSKOBMDSA-N

SMILES: O(C)[C@@H]1[C@@]2(O[C@](O)([C@H](C)C1)C(=O)C(=O)N3[C@](C(=O)O[C@H](\C(=C\[C@H]4C[C@@H](OC)[C@@H](Cl)CC4)\C)[C@H](C)[C@@H](O)CC(=O)[C@H](CC)/C=C(\C)/C[C@H](C)C[C@@H]2OC)(CCCC3)[H])[H]

Synonyms:

• (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-3-[(1E)-2-[(1R,3R,4S)-4-Chloro-3-methoxycyclohexyl]-1-methylethenyl]-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone
• (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-3-{(1E)-1-[(1R,3R,4R)-4-chloro-3-methoxycyclohexyl]prop-1-en-2-yl}-8-ethyl-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone
• (3S,4S,5S,8R,12S,14S,15R,16S,18R,19R,26aS)-3-{(E)-2-[(1R,3R,4S)-4-chloro-3-methoxycyclohexyl]-1-methylethenyl}-8-ethyl-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone
• 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 3-[(1E)-2-[(1R,3R,4S)-4-chloro-3-methoxycyclohexyl]-1-methylethenyl]-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
• 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 3-[2-(4-chloro-3-methoxycyclohexyl)-1-methylethenyl]-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-, [3S-[3R*[E(1S*,3S*,4R*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-
• 33-Epichloro-33-desoxyascomycin
• 33-epi-Chloro-33-desoxyascomycin
• Asm 981
• Elidel
• Picrolimus
• Sdz-Asm 981
• PiMecroliMus(Elidel, SDZ-ASM-981)
• Pimecrolimus
• Unii-7kyv510875
• PiMecroliMus(Elidel)

Pimecrolimus

CAS: 137071-32-0

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₄₃H₆₈ClNO₁₁

Color and Shape: White Off-White Powder

Molecular weight: 809.44809

Ref: 45-1539100

Pimecrolimus

CAS: 137071-32-0

Formula: C₄₃H₆₈ClNO₁₁

Purity: 96%

Color and Shape: Solid

Molecular weight: 810.4531

Ref: IN-DA00708B

Pimecrolimus

CAS: 137071-32-0

Pimecrolimus

Purity: 98%

Molecular weight: 810.45g/mol

Ref: 54-OR1026405

Pimecrolimus

CAS: 137071-32-0

Formula: C₄₃H₆₈ClNO₁₁

Color and Shape: White To Off-White Solid

Molecular weight: 810.46

Ref: 4Z-P-206001

Pimecrolimus

CAS: 137071-32-0

Pimecrolimus

Purity: ≥98%

Molecular weight: 810.45g/mol

Ref: 54-BUP11057

Pimecrolimus

CAS: 137071-32-0

Formula: C₄₃H₆₈ClNO₁₁

Purity: >95.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 810.46

Ref: 3B-P2493

Pimecrolimus

CAS: 137071-32-0

Formula: C₄₃H₆₈ClNO₁₁

Purity: ≥ 97.0%

Color and Shape: White to beige powder

Molecular weight: 810.45

Ref: 7W-GW2192

Pimecrolimus

CAS: 137071-32-0

Pimecrolimus, a calcineurin inhibitor, binds FKBP-12, blocking calcium-dependent signals.

Formula: C₄₃H₆₈ClNO₁₁

Purity: 99.53% - 99.87%

Color and Shape: White Crystalline Powder

Molecular weight: 810.45

Ref: TM-T2648

Pimecrolimus

Controlled Product

CAS: 137071-32-0

Formula: C₄₃H₆₈ClNO₁₁

Color and Shape: Neat

Molecular weight: 810.45

Ref: TR-P445000

17-epi-Pimecrolimus (>80%)

Controlled Product

CAS: 137071-32-0

Formula: C₄₃H₆₈ClNO₁₁

Purity: >80%

Color and Shape: Neat

Molecular weight: 810.45

Ref: TR-E588045

Pimecrolimus

CAS: 137071-32-0

Immune suppressant; prevents pro-inflammatory cytokine release

Formula: C₄₃H₆₈ClNO₁₁

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 810.45 g/mol

Ref: 3D-FE27046

4-Epi-14,15-Dehydrated Pimecrolimus

Controlled Product

CAS: 137071-32-0

Formula: C₄₃H₆₆ClNO₁₀

Color and Shape: Neat

Molecular weight: 792.44

Ref: TR-E588040