CAS: 137071-32-0 - Pimecrolimus

Formula: C₄₃H₆₈ClNO₁₁

InChI: InChI=1S/C43H68ClNO11/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)45-16-12-11-13-32(45)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-31(44)35(22-29)52-7/h18,20,25,27-33,35-39,46,51H,10-17,19,21-23H2,1-9H3/b24-18+,26-20+/t25-,27+,28+,29-,30+,31-,32-,33-,35+,36-,37-,38+,39+,43+/m0/s1

InChI key: InChIKey=KASDHRXLYQOAKZ-XDSKOBMDSA-N

SMILES: O=C1C(=O)C2(O)OC(C(OC)CC(C)CC(=CC(C(=O)CC(O)C(C)C(OC(=O)C3N1CCCC3)C(=CC4CCC(Cl)C(OC)C4)C)CC)C)C(OC)CC2C

Synonyms:

• (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-3-[(1E)-2-[(1R,3R,4S)-4-Chloro-3-methoxycyclohexyl]-1-methylethenyl]-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone
• (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-3-{(1E)-1-[(1R,3R,4R)-4-chloro-3-methoxycyclohexyl]prop-1-en-2-yl}-8-ethyl-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone
• (3S,4S,5S,8R,12S,14S,15R,16S,18R,19R,26aS)-3-{(E)-2-[(1R,3R,4S)-4-chloro-3-methoxycyclohexyl]-1-methylethenyl}-8-ethyl-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone
• 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 3-[(1E)-2-[(1R,3R,4S)-4-chloro-3-methoxycyclohexyl]-1-methylethenyl]-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
• 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 3-[2-(4-chloro-3-methoxycyclohexyl)-1-methylethenyl]-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-, [3S-[3R*[E(1S*,3S*,4R*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-
• 33-Epichloro-33-desoxyascomycin
• 33-epi-Chloro-33-desoxyascomycin
• Asm 981
• Elidel
• Picrolimus
• Sdz-Asm 981

Pimecrolimus

CAS: 137071-32-0

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

• Formula: C₄₃H₆₈ClNO₁₁
• Color and Shape: White Off-White Powder
• Molecular weight: 809.44809

Pimecrolimus

CAS: 137071-32-0

• Formula: C₄₃H₆₈ClNO₁₁
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 810.4531

Pimecrolimus

CAS: 137071-32-0

• Formula: C₄₃H₆₈ClNO₁₁
• Color and Shape: White To Off-White Solid
• Molecular weight: 810.46

Pimecrolimus

CAS: 137071-32-0

• Formula: C₄₃H₆₈ClNO₁₁
• Purity: ≥ 97.0%
• Color and Shape: White to beige powder
• Molecular weight: 810.45

Pimecrolimus

CAS: 137071-32-0

Pimecrolimus, a calcineurin inhibitor, binds FKBP-12, blocking calcium-dependent signals.

• Formula: C₄₃H₆₈ClNO₁₁
• Purity: 99.53% - 99.87%
• Color and Shape: White Crystalline Powder
• Molecular weight: 810.45

Pimecrolimus

CAS: 137071-32-0

• Formula: C₄₃H₆₈ClNO₁₁
• Color and Shape: Neat
• Molecular weight: 810.45

17-epi-Pimecrolimus (>80%)

CAS: 137071-32-0

• Formula: C₄₃H₆₈ClNO₁₁
• Purity: >80%
• Color and Shape: Neat
• Molecular weight: 810.45

Pimecrolimus

CAS: 137071-32-0

Immune suppressant; prevents pro-inflammatory cytokine release

• Formula: C₄₃H₆₈ClNO₁₁
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 810.45 g/mol

4-Epi-14,15-Dehydrated Pimecrolimus

CAS: 137071-32-0

• Formula: C₄₃H₆₆ClNO₁₀
• Color and Shape: Neat
• Molecular weight: 792.44