CAS 137076-54-1

TRI-TERT-BUTYL 1,4,7,10-TETRAAZACYCLODODECANE-TETRAACETATE

Description:

Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-tetraacetate is a complex organic compound characterized by its unique cyclic structure and multiple functional groups. It features a tetraazacyclododecane backbone, which consists of a 12-membered ring containing four nitrogen atoms, contributing to its chelating properties. The presence of four tert-butyl groups enhances its steric bulk, influencing its solubility and reactivity. The tetraacetate moieties provide additional functionalization, allowing for potential interactions with metal ions, making it useful in coordination chemistry. This compound is typically synthesized through multi-step organic reactions, and its stability and solubility can vary depending on the solvent and conditions used. Due to its structural complexity, it may exhibit interesting properties such as selective binding to certain metal ions, which can be exploited in various applications, including catalysis and materials science. Safety data and handling precautions should be observed, as with any chemical substance, to mitigate risks associated with its use.

Formula: C₂₈H₅₂N₄O₈

InChI: InChI=1/C28H52N4O8/c1-26(2,3)38-23(35)19-30-12-10-29(18-22(33)34)11-13-31(20-24(36)39-27(4,5)6)15-17-32(16-14-30)21-25(37)40-28(7,8)9/h10-21H2,1-9H3,(H,33,34)

SMILES: CC(C)(C)OC(=O)CN1CCN(CCN(CCN(CC1)CC(=O)OC(C)(C)C)CC(=O)OC(C)(C)C)CC(=O)O

Synonyms:

• [4,7,10-Tris(2-Tert-Butoxy-2-Oxoethyl)-1,4,7,10-Tetraazacyclododecan-1-Yl]Acetic Acid
• Tri-tert-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate

Tri-tert-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate

CAS: 137076-54-1

Formula: C₂₈H₅₂N₄O₈

Purity: >97.0%(T)

Color and Shape: White to Gray to Red powder to crystal

Molecular weight: 572.74

Ref: 3B-T2642

DOTA(OtBu)₃

CAS: 137076-54-1

t-Butyl ester-protected DOTA derivative allows the selective conjugation of the macrocyclic chelator to peptides during Fmoc-SPPS. DOTA forms highly stable chelates with radioactive isotopes of Ga,In,and Y, as well as with radionuclides of Lu, Gd, and other lanthanides.

Formula: C₂₈H₅₂N₄O₈

Purity: 98.6%

Color and Shape: White Powder

Molecular weight: 572.74

Ref: 01-4029066

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,4,7-tris(1,1-dimethylethyl) ester

CAS: 137076-54-1

Formula: C₂₈H₅₂N₄O₈

Purity: 97%

Color and Shape: Solid

Molecular weight: 572.7345

Ref: IN-DA0012TN

DOTA-tri(t-butyl ester)

CAS: 137076-54-1

DOTA-tri(t-butyl ester) is used to make G3 MRI contrast agents for MR angiography and tumor imaging.

Formula: C₂₈H₅₂N₄O₈

Color and Shape: Solid

Molecular weight: 572.73

Ref: TM-T38783

Gadobutrol Impurity 87

CAS: 137076-54-1

Formula: C₂₈H₅₂N₄O₈

Molecular weight: 572.74

Ref: 4Z-G-31111

DOTA-tris(tBu)ester

CAS: 137076-54-1

DOTA-tris(tBu)ester

Formula: C₂₈H₅₂N₄O₈

Purity: 97%

Color and Shape: white to off-white solid

Molecular weight: 572.73447g/mol

Ref: 54-OR904563

DOTA-tris (t-Bu ester) (~90%)

Controlled Product

CAS: 137076-54-1

Applications DOTA-tris (t-Bu ester), is a Bifunctional chelator, that can be used in the preparation of gadolinium complexes as MRI blood contrast agents.

Formula: C₂₈H₅₂N₄O₈

Purity: ~90%

Color and Shape: Neat

Molecular weight: 572.73

Ref: TR-D494855

2-(4,7,10-TRIS(2-TERT-BUTOXY-2-OXOETHYL)-1,4,7,10-TETRAAZACYCLODODECAN-1-YL)ACETIC ACID

CAS: 137076-54-1

Purity: 95%

Color and Shape: Solid

Molecular weight: 572.7440186

Ref: 10-F792189

DOTA(tBu)3-OH

CAS: 137076-54-1

DOTA(tBu)3-OH is a Building Block that is used in peptide synthesis. It can be used as a condensation reagent or as a building block for the synthesis of peptides and antibodies. DOTA(tBu)3-OH is also an additive for labelling and building blocks for peptide synthesis. DOTA(tBu)3-OH is stable and not toxic to cells, making it useful in cell culture applications. It has been shown to react with the side chain amino groups of lysine residues on proteins, including antibody molecules.

Formula: C₂₈H₅₂N₄O₈

Purity: Min. 95%

Molecular weight: 572.73 g/mol

Ref: 3D-DTB-5003-PI

DOTA-Tris(tBu)

CAS: 137076-54-1

Formula: C₂₈H₅₂N₄O₈

Molecular weight: 572.74

Ref: ST-EA-CP-G39012

Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate

CAS: 137076-54-1

Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (TBA) is a gadolinium chelate that is used as a contrast agent in magnetic resonance imaging. TBA binds to the malignant cells and shows an increase in uptake of the gadolinium contrast agent. TBA has been shown to be effective in the diagnosis of cancerous brain tissue and is also able to detect cancer cells in animals. TBA has shown some efficacy against bacterial infection by binding to the cell membrane and inhibiting protein synthesis. It is also able to act synergistically with antibiotics such as penicillin or ampicillin to kill bacteria more effectively.

Formula: C₂₈H₅₂N₄O₈

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 572.73 g/mol

Ref: 3D-FT49920