CAS 13710-19-5

tolfenamic acid

Description:

Tolfenamic acid is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the anthranilic acid derivative class. It is primarily used for its analgesic and anti-inflammatory properties, making it effective in treating pain and inflammation associated with various conditions. The chemical structure of tolfenamic acid features a carboxylic acid group and an aromatic ring, which contribute to its pharmacological activity. It exhibits moderate solubility in water and is more soluble in organic solvents, reflecting its lipophilic nature. Tolfenamic acid functions by inhibiting cyclooxygenase (COX) enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of inflammation and pain. The substance is typically administered in oral form and is known for its relatively rapid onset of action. Additionally, it has been studied for its potential use in veterinary medicine, particularly in treating pain in animals. As with other NSAIDs, it may have side effects, including gastrointestinal disturbances, and should be used with caution in individuals with certain health conditions.

Formula: C₁₄H₁₂ClNO₂

InChI: InChI=1/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18)

InChI key: InChIKey=YEZNLOUZAIOMLT-UHFFFAOYSA-N

SMILES: N(C1=C(C(O)=O)C=CC=C1)C2=C(C)C(Cl)=CC=C2

Synonyms:

• 1,2-Distearoyl-sn-glycero-3-phosphocholine, DSPC
• 2 (3-Chloro-2-Methylanilino)Benzoic Acid
• 2-((3-Chloro-2-Methylphenyl)Amino)-Benzoicaci
• 2-(3-Chloro-O-Toluidino)Benzoic Acid
• 2-[(3-Chloro-2-Methylphenyl)Amino]Benzoic Acid
• 2-[(4-Chloro-3-Methylphenyl)Amino]Benzoic Acid
• Anthranilic acid, N-(3-chloro-o-tolyl)-
• Benzoic acid, 2-[(3-chloro-2-methylphenyl)amino]-
• Clotam
• Gea 6414
• Gea6414
• Labotest-Bb Lt00772313
• Migea
• N-(2-Methyl-3-chlorophenyl)anthranilic acid
• N-(3-Chloro-o-tolyl)anthranilic acid
• N-(3-Chloro-ortho-tolyl) anthranilic acid
• Tolfedine
• Tolfenamate
• Tolfine
• n-(3-chloro-o-tolyl)-anthranilicacid
• Tolfenamic
• n-(3-chloro-o-tolyl)-anthranilicaci
• TOLFENAMIC ACID
• N-(3-CHLORO-2-METHYLPHENYL)ANTHRANILIC ACID
• 2 (3-Chloro-2-methylanilino)benzoic acid, 2-([3-Chloro-2-methylphenyl]amino)benzoic acid
• n-(2-methyl-3-chlorophenyl)anthranilicacid

Tolfenamic Acid

CAS: 13710-19-5

Formula: C₁₄H₁₂ClNO₂

Purity: >97.0%(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 261.71

Ref: 3B-C2064

Tolfenamic acid, 99+%

CAS: 13710-19-5

Tolfenamic acid is a non-steroidal anti-inflammatory agent. It interferes with synthesis of -amyloid precursor protein, and thus A peptides, by promoting degradation of an essential transcription factor. It inhibits fMLP- and A23187-induced Ca2+ influx in human PMNL with an IC50 value of approximate

Formula: C₁₄H₁₂ClNO₂

Purity: 99+%

Molecular weight: 261.71

Ref: 02-J61256

Tolfenamic Acid

CAS: 13710-19-5

Color and Shape: Neat

Ref: 61-FOR3395.00

TOLFENAMIC ACID CRS

CAS: 13710-19-5

TOLFENAMIC ACID CRS

Formula: C₁₄H₁₂ClNO₂

Color and Shape: Added Modified

Molecular weight: 261.7036

Ref: 41-Y0000154

2-[(3-chloro-2-methylphenyl)amino]benzoic acid

CAS: 13710-19-5

Formula: C₁₄H₁₂ClNO₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 261.7036

Ref: IN-DA003SAR

Tolfenamic Acid

CAS: 13710-19-5

Tolfenamic Acid (GEA 6414) is one of the class of non-steroidal anti-inflammatory drugs (NSAIDs). It is used to treat the symptoms of migraine.

Formula: C₁₄H₁₂ClNO₂

Purity: 99.71% - 99.97%

Color and Shape: Solid

Molecular weight: 261.70

Ref: TM-T0784

Tolfenamic Acid

CAS: 13710-19-5

Formula: C₁₄H₁₂ClNO₂

Color and Shape: White To Off-White Solid

Molecular weight: 261.71

Ref: 4Z-T-962

Tolfenamic Acid

CAS: 13710-19-5

Tolfenamic Acid

Purity: ≥98%

Molecular weight: 261.7g/mol

Ref: 54-BUP17586

2-((3-Chloro-2-Methylphenyl)Amino)Benzoic Acid

CAS: 13710-19-5

2-((3-Chloro-2-Methylphenyl)Amino)Benzoic Acid

Purity: 98%

Molecular weight: 261.70g/mol

Ref: 54-OR1009617

Tolfenamic-d4 Acid (Benzoic-3,4,5,6-d4)

CAS: 1246820-82-5, 13710-19-5

Purity: 98 atom % D

Molecular weight: 265.73

Ref: 3U-D7725

Tolfenamic acid 1000 µg/mL in Acetonitrile

Controlled Product

CAS: 13710-19-5

Formula: C₁₄H₁₂ClNO₂

Color and Shape: Single Solution

Molecular weight: 261.70

Ref: 04-A17591000AL-1000

Tolfenamic Acid

Controlled Product

CAS: 13710-19-5

Formula: C₁₄H₁₂ClNO₂

Color and Shape: Neat

Molecular weight: 261.70

Ref: 86-MM3395.00

Tolfenamic acid

Controlled Product

CAS: 13710-19-5

Formula: C₁₄H₁₂ClNO₂

Color and Shape: Neat

Molecular weight: 261.70

Ref: 04-C17591000

Tolfenamic Acid

Controlled Product

CAS: 13710-19-5

Applications Non-steroidal anti-inflammatory drugs (NSAIDs). A derivative of anthranilic acid, related structurally to Mefenamic and Flufenamic acids. Anti-inflammatory, analgesic.
References Pentikaeinen, P., et al.: Eur. J. Clin. Pharmacol., 19, 359 (1981), Bundscherer, A., et al.: Oncol. Rep., 19, 547 (2008), Elwood, P., et al.: Lancet, 373, 1301 (2009),

Formula: C₁₄H₁₂ClNO₂

Color and Shape: Off-White

Molecular weight: 261.70

Ref: TR-T535300

Tolfenamic Acid

CAS: 13710-19-5

Formula: C₁₄H₁₂ClNO₂

Purity: 97%

Color and Shape: No data available.

Molecular weight: 261.71

Ref: 10-F519604

Tolfenamic Acid

CAS: 13710-19-5

Tolfenamic acid is a non-steroidal anti-inflammatory drug that has been shown to inhibit the MCL-1 protein, which is involved in the regulation of programmed cell death. It has been used for the treatment of bowel disease and can be given orally or rectally. Tolfenamic acid may be effective against inflammatory bowel diseases such as ulcerative colitis and Crohn's disease. Tolfenamic acid binds to anionic sites on the matrix of cartilage and inhibits the production of prostaglandin E2 by inhibiting cyclooxygenase activity. Tolfenamic acid has also been shown to reduce pain by inhibiting the enzyme COX-2, which is associated with inflammation. The drug also has a strong effect on human polymorphonuclear leukocytes (PMN).

Formula: C₁₄H₁₂ClNO₂

Purity: Min. 97%

Color and Shape: Powder

Molecular weight: 261.7 g/mol

Ref: 3D-FT28306