CAS 137159-92-3

Aptiganel

Description:

Aptiganel, with the CAS number 137159-92-3, is a chemical compound that has been studied primarily for its potential therapeutic applications, particularly in the context of neurological disorders. It is classified as a non-competitive antagonist of the NMDA (N-methyl-D-aspartate) receptor, which plays a crucial role in synaptic plasticity and memory function. By modulating the activity of this receptor, Aptiganel may help in reducing excitotoxicity, a process that can lead to neuronal damage and is implicated in various conditions such as stroke and neurodegenerative diseases. The compound has been evaluated in clinical settings, focusing on its efficacy and safety profile. Its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are essential for understanding its therapeutic potential. As with many investigational drugs, ongoing research continues to explore its full range of effects, optimal dosing, and potential side effects. Overall, Aptiganel represents a significant area of interest in the field of neuropharmacology.

Formula: C₂₀H₂₁N₃

InChI: InChI=1S/C20H21N3/c1-3-15-8-6-11-17(14-15)23(2)20(21)22-19-13-7-10-16-9-4-5-12-18(16)19/h4-14H,3H2,1-2H3,(H2,21,22)

InChI key: InChIKey=BFNCJMURTMZBTE-UHFFFAOYSA-N

SMILES: N(C(N(C)C1=CC(CC)=CC=C1)=N)C=2C3=C(C=CC2)C=CC=C3

Synonyms:

• N-(3-Ethylphenyl)-N-methyl-N′-1-naphthalenylguanidine
• Guanidine, N-(3-ethylphenyl)-N-methyl-N′-1-naphthalenyl-
• 1-(3-Ethylphenyl)-1-methyl-2-naphthalen-1-ylguanidine
• Aptiganel

Guanidine, N-(3-ethylphenyl)-N-methyl-N'-1-naphthalenyl-

CAS: 137159-92-3

Formula: C₂₀H₂₁N₃

Purity: 95%

Molecular weight: 303.4008

Ref: IN-DA0012VJ

Aptiganel

CAS: 137159-92-3

Aptiganel

Purity: ≥98%

Molecular weight: 303.4g/mol

Ref: 54-BUP03378

Aptiganel

CAS: 137159-92-3

Aptiganel (CNS-1102) is a non-competitive NMDA antagonist, a peptide that may be used to study acute ischemic stroke.

Formula: C₂₀H₂₁N₃

Purity: 98.13% - 98.90%

Color and Shape: Solid

Molecular weight: 303.4

Ref: TM-T26645

Aptiganel

CAS: 137159-92-3

Aptiganel (CAS No. 137159-92-3) is a research tool that can be used to study the interaction of proteins and peptides with ion channels. It is an inhibitor of ion channels that blocks the flow of ions through them, thereby preventing the generation of action potentials. Aptiganel is a potent inhibitor of voltage-dependent calcium channels, which are found in neurons and muscle cells. This drug binds to ligands on the extracellular side of ion channel receptors and prevents ligand binding to the receptor, blocking ion flow. Aptiganel has been shown to inhibit voltage-gated potassium channels in rat dorsal root ganglion cells, human neuroblastoma cells grown in culture, and cultured mouse embryo spinal cord neurons. Aptiganel also inhibits voltage-gated sodium channels in rat dorsal root ganglion cells and cultured mouse embryo spinal cord neurons.

Formula: C₂₀H₂₁N₃

Purity: Min. 95%

Molecular weight: 303.4 g/mol

Ref: 3D-MFA15992