CAS 137219-37-5

Plitidepsin

Description:

Plitidepsin, with the CAS number 137219-37-5, is a synthetic cyclic peptide that has garnered attention for its potential therapeutic applications, particularly in oncology and antiviral treatments. It is derived from the marine organism Aplidium albicans and exhibits a unique mechanism of action by inhibiting the eukaryotic translation elongation factor 1A (eEF1A), which is crucial for protein synthesis. This inhibition leads to the disruption of cellular processes, ultimately inducing apoptosis in cancer cells. Plitidepsin has shown promise in preclinical and clinical studies, particularly against various types of cancer and viral infections, including those caused by coronaviruses. Its pharmacological profile includes moderate solubility in water and a favorable safety profile, although side effects may occur, as with many therapeutic agents. The compound is typically administered intravenously, and ongoing research continues to explore its efficacy and safety in different patient populations. Overall, Plitidepsin represents a novel approach in the search for effective treatments against challenging diseases.

Formula: C₅₇H₈₇N₇O₁₅

InChI: InChI=1/C57H87N7O15/c1-15-33(8)46-44(66)29-45(67)79-49(32(6)7)48(68)34(9)50(69)58-39(26-30(2)3)54(73)64-25-17-19-41(64)56(75)62(13)43(28-37-20-22-38(77-14)23-21-37)57(76)78-36(11)47(52(71)59-46)60-51(70)42(27-31(4)5)61(12)55(74)40-18-16-24-63(40)53(72)35(10)65/h20-23,30-34,36,39-44,46-47,49,66H,15-19,24-29H2,1-14H3,(H,58,69)(H,59,71)(H,60,70)/t33-,34+,36-,39-,40-,41?,42+,43?,44-,46+,47+,49-/m0/s1

Synonyms:

• Aplidine
• 2-9-Didemnin B, 2-(1-(1,2-dioxopropyl)-L-proline)-
• Aplidin
• Dehydrodidemnin B
• Didemnin A, N-(1-(1,2-dioxopropyl)-L-prolyl)-
• L-Tyrosine, 1-(1,2-dioxopropyl)-L-prolyl-N-methyl-D-leucyl-L-threonyl-(3S,4R,5S)-4-amino-3-hydroxy-5-methylheptanoyl-(2S,4S)-4-hydroxy-2,5-dimethyl-3-oxohexanoyl-L-leucyl-L-prolyl-N,O-dimethyl-, (8-3)-lactone
• 1-(2-oxopropanoyl)-L-prolyl-N-[(6S,7R,10R,11S,15S,17R,20S,25aS)-11-hydroxy-3-(4-methoxybenzyl)-2,6,17-trimethyl-15-(1-methylethyl)-10-[(1S)-1-methylpropyl]-20-(2-methylpropyl)-1,4,8,13,16,18,21-heptaoxodocosahydro-15H-pyrrolo[2,1-f][1,15,4,7,10,20]dioxatetraazacyclotricosin-7-yl]-N2-methyl-D-leucinamide
• 3,6-Anhydro-(N-{(2S,4S)-4-[(3S,4R,5S)-3-hydroxy-4-{[N-(2-oxo-propanoyl)-L-prolyl-N-Methyl-D-leucyl-L-threonyl]aMino}-5-Methyl-heptanoyloxy]-2,5-diMethyl-3-oxohexanoyl}-L-leucyl-L-prolyl-N
• Plitidepsin
• (2S)-N-[(2R)-1-[[(3S,6S,8S,12S,13R,16S,17R,20S,23S)-13-[(2S)-butan-2-yl]-12-hydroxy-20-[(4-methoxyphenyl)methyl]-6,17,21-trimethyl-3-(2-methylpropyl)-2,5,7,10,15,19,22-heptaoxo-8-propan-2-yl-9,18-dioxa-1,4,14,21-tetrazabicyclo[21.3.0]hexacosan-16-yl]amino]-4-methyl-1-oxopentan-2-yl]-N-methyl-1-(2-oxopropanoyl)pyrrolidine-2-carboxamide
• Plitidepsin (Aplidine)
• Plitidepsin top3

Aplidine

CAS: 137219-37-5

Aplidine

Purity: ≥98%

Molecular weight: 1110.34g/mol

Ref: 54-BUP03223

Plitidepsin (Aplidine)

CAS: 137219-37-5

Formula: C₅₇H₈₇N₇O₁₅

Molecular weight: 1110.36

Ref: 4Z-PP-362001

Aplidine

CAS: 137219-37-5

Aplidine possesses antiviral activity against SARS-CoV-2(IC90 = 0.88 nM).

Formula: C₅₇H₈₇N₇O₁₅

Purity: 99.86%

Color and Shape: Solid

Molecular weight: 1110.34

Ref: TM-T9715

Plitidepsin

CAS: 137219-37-5

Plitidepsin is a natural product first isolated from a marine tunicate Aplidium albicans. Plitidepsin has anti-cancer properties as it can induce cell cycle arrest, apoptosis and was also reported to have anti-angiogenic properties. Plitidepsin possesses a potent antiviral activity in vitro against SARS-CoV-2 with IC90 = 0.88nM, which results to be 27.5-fold more potent than the RdRp inhibitor remdesivir. Plitidepsin targets the host protein synthesis factor, eEF1A, and was shown to greatly reduce the subgenomic RNA expression during viral infection.

Formula: C₅₇H₈₇N₇O₁₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1,110.34 g/mol

Ref: 3D-FP178389