CAS 137234-76-5

(aR,​bR)​-​rel-6-​Chloro-​a-​(2,​4-​difluorophenyl)​-​5-​fluoro-​b-​methyl-​a-​(1H-​1,​2,​4-​triazol-​1-​ylmethyl)​-4-​pyrimidineethanol

Controlled Product

CAS: 137234-76-5

Applications (αR,​βR)​-​rel-6-​Chloro-​α-​(2,​4-​difluorophenyl)​-​5-​fluoro-​β-​methyl-​α-​(1H-​1,​2,​4-​triazol-​1-​ylmethyl)​-4-​pyrimidineethanol is an intermediate in synthesizing rel-(R,R)-Voriconazole (V759990), The (R,R)-enantiomer of Voriconazole. An antifungal (systemic). An ergosterol biosynthesis inhibitor.
References Sanati, H., et al.: Antimicrob. Ag. Chemother., 41, 2492 (1997)

Formula: C₁₆H₁₃ClF₃N₅O

Color and Shape: Neat

Molecular weight: 383.76

Ref: TR-C585303

(Αr,βr)-rel-6-chloro-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol

CAS: 137234-76-5

(Ar,βR)-rel-6-chloro-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol is a potent agonist of the ion channels TRPM8 and TRPA1. It has been shown to bind to the extracellular loops of these ion channels and activate them in a dose dependent manner. It also inhibits the activation of TRPM8 by its endogenous agonist menthol. It is suitable for research use as a tool to study protein interactions and receptor function.

Formula: C₁₆H₁₄Cl₂F₃N₅O

Purity: Min. 95%

Molecular weight: 420.2 g/mol

Ref: 3D-MFA23476