CAS 137281-23-3: Pemetrexed

Description: Pemetrexed is a multi-targeted antifolate chemotherapy agent primarily used in the treatment of certain types of cancer, particularly non-small cell lung cancer and mesothelioma. Its mechanism of action involves the inhibition of several enzymes in the folate pathway, including thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase, which are crucial for DNA synthesis and cell proliferation. Pemetrexed is administered intravenously and is often given in combination with other chemotherapeutic agents to enhance its efficacy. The drug is characterized by its structural complexity, featuring a pyrimidine ring and multiple functional groups that contribute to its biological activity. Common side effects include myelosuppression, gastrointestinal disturbances, and fatigue, necessitating careful monitoring during treatment. Additionally, patients may require supplementation with folic acid and vitamin B12 to mitigate some of the drug's toxicities. Overall, pemetrexed represents a significant advancement in targeted cancer therapy, demonstrating improved outcomes in specific patient populations.

Formula: C₂₀H₂₁N₅O₆

InChI: InChI=1S/C20H21N5O6/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29)/t13-/m0/s1

InChI key: InChIKey=WBXPDJSOTKVWSJ-ZDUSSCGKSA-N

SMILES: O=C1N=C(N)NC=2NC=C(C12)CCC3=CC=C(C=C3)C(=O)NC(C(=O)O)CCC(=O)O

Synonyms:

• (S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid
• 1H-Pyrrolo[2,3-d]pyrimidine, <span class="text-smallcaps">L</span>-glutamic acid deriv.
• 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H pyrodo[2,3-d]Pyrimidin-5-yl)ethyl]-benzoic Acid
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-
• L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-
• N-(4-(2-(2-Amino-3,4-dihydro-4-oxo-7H-pyrrolo(2,3-d)pyrimdin-5-yl)ethyl)benzoyl)glutamic acid
• N-(4-[2-(2-Amino-4,7-Dihydro-4-oxo-1H-pyrrolo)[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-Gluamic Acid
• N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]L-Glutamic acid
• N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid
• NSC 698037
• Pefloxacinmesylate Pharma-0549
• Pemetrexed
• Pemetrexed Acid
• disodium (2R)-2-({4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}amino)pentanedioate
• L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-
• 1H-Pyrrolo[2,3-d]pyrimidine, L-glutamic acid deriv.

Pemetrexed

CAS: 137281-23-31916503-69-9

• Formula: C₂₀H₂₁N₅O₆
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Blue powder to crystal
• Molecular weight: 427.42

Pemetrexed

CAS: 137281-23-3

Pemetrexed (LY-231514 Disodium Hydrate), a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate …

• Formula: C₂₀H₂₁N₅O₆
• Purity: 98.1% - 99.92%
• Color and Shape: Similar To White Powder
• Molecular weight: 427.41

L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-

CAS: 137281-23-3

• Formula: C₂₀H₂₁N₅O₆
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 427.41063999999994

Pemetrexed

CAS: 137281-23-3

• Formula: C₂₀H₂₁N₅O₆
• Color and Shape: White To Off-White Solid
• Molecular weight: 427.42

Pemetrexed Hydrate

CAS: 137281-23-3

• Molecular weight: 427.41g/mol

(S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid

CAS: 137281-23-3

• Purity: 95.0%
• Color and Shape: Solid, Blue powder
• Molecular weight: 427.4169921875

Pemetrexed - Bio-X ™

CAS: 137281-23-3

Pemetrexed is a chemotherapy drug that belongs to the class of drugs called folate antimetabolites. …

• Formula: C₂₀H₂₁N₅O₆
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 427.41 g/mol

Pemetrexed

CAS: 137281-23-3

Thymidylate synthase inhibitor; antifolate antineoplastic agent

• Formula: C₂₀H₂₁N₅O₆
• Purity: Min. 95%
• Color and Shape: White Powder
• Molecular weight: 427.41 g/mol

N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid

CAS: 137281-23-3

Applications N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid, referred to as Pemetrexed, is used in the treatment of malignant pleural …

• Formula: C₂₀H₂₁N₅O₆
• Color and Shape: Neat
• Molecular weight: 427.41