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CAS 137330-52-0

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Voriconazole

Description:
Voriconazole is an antifungal medication primarily used to treat serious fungal infections, particularly those caused by Aspergillus species and Candida. It belongs to the triazole class of antifungals, which function by inhibiting the enzyme lanosterol 14α-demethylase, crucial for ergosterol synthesis in fungal cell membranes. Voriconazole is characterized by its broad-spectrum activity against various fungi, including both yeasts and molds. It is typically administered orally or intravenously and is known for its good bioavailability and ability to penetrate tissues effectively. The substance is also notable for its pharmacokinetic properties, including a relatively long half-life, which allows for less frequent dosing. Voriconazole can exhibit variable metabolism due to genetic polymorphisms in cytochrome P450 enzymes, leading to potential drug interactions. Common side effects may include visual disturbances, liver enzyme elevations, and skin rashes. Due to its efficacy and safety profile, voriconazole is a critical option in the management of invasive fungal infections, particularly in immunocompromised patients.
Formula:C16H14F3N5O
InChI:InChI=1/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3
SMILES:CC(c1c(cncn1)F)C(Cn1cncn1)(c1ccc(cc1F)F)O
Synonyms:
  • 2-(2,4-Difluorophenyl)-3-(5-Fluoropyrimidin-4-Yl)-1-(1H-1,2,4-Triazol-1-Yl)Butan-2-Ol
  • (2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol
  • (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
  • (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol L(-)-Camphorsulfonate
  • (2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyriMidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol L(-)-CaMphorsulfonate
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Found 5 products.