CAS 137339-65-2

ser-phe-leu-leu-arg-asn-pro-asn-asp-*lys-tyr-glu-

Description:

The chemical substance with the name "ser-phe-leu-leu-arg-asn-pro-asn-asp-lys-tyr-glu-" and CAS number 137339-65-2 is a peptide composed of a specific sequence of amino acids. This peptide features a combination of polar, non-polar, and charged residues, which contribute to its unique properties and biological functions. The presence of amino acids such as serine, phenylalanine, leucine, arginine, asparagine, proline, lysine, tyrosine, and glutamic acid suggests that it may play a role in various physiological processes, potentially including signaling pathways or structural functions in proteins. The sequence indicates a potential for interactions with other biomolecules, influenced by the side chains of the constituent amino acids. Additionally, the peptide's solubility, stability, and reactivity can be affected by its length and composition, making it of interest in fields such as biochemistry, pharmacology, and biotechnology. Further studies would be necessary to elucidate its specific biological activity and potential applications.

Formula: C₈₁H₁₁₈N₂₀O₂₃

InChI: InChI=1/C81H118N20O23/c1-43(2)34-53(93-71(114)54(35-44(3)4)94-73(116)55(92-67(110)49(83)42-102)36-45-16-7-5-8-17-45)70(113)90-51(21-13-31-88-81(86)87)69(112)98-59(40-64(85)105)79(122)101-33-15-22-61(101)76(119)97-57(39-63(84)104)74(117)96-58(41-66(108)109)75(118)89-50(20-11-12-30-82)68(111)95-56(37-47-24-26-48(103)27-25-47)72(115)91-52(28-29-65(106)107)78(121)100-32-14-23-62(100)77(120)99-60(80(123)124)38-46-18-9-6-10-19-46/h5-10,16-19,24-27,43-44,49-62,102-103H,11-15,20-23,28-42,82-83H2,1-4H3,(H2,84,104)(H2,85,105)(H,89,118)(H,90,113)(H,91,115)(H,92,110)(H,93,114)(H,94,116)(H,95,111)(H,96,117)(H,97,119)(H,98,112)(H,99,120)(H,106,107)(H,108,109)(H,123,124)(H4,86,87,88)/t49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-/m0/s1

SMILES: CC(C)C[C@@H](C(=N[C@@H](CCCNC(=N)N)C(=N[C@@H](CC(=N)O)C(=O)N1CCC[C@H]1C(=N[C@@H](CC(=N)O)C(=N[C@@H](CC(=O)O)C(=N[C@@H](CCCCN)C(=N[C@@H](Cc1ccc(cc1)O)C(=N[C@@H](CCC(=O)O)C(=O)N1CCC[C@H]1C(=N[C@@H](Cc1ccccc1)C(=O)O)O)O)O)O)O)O)O)O)N=C([C@H](CC(C)C)N=C([C@H](Cc1ccccc1)N=C([C@H](CO)N)O)O)O

Synonyms:

• Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe

TRAP-14

CAS: 137339-65-2

Cloning and expression of a functional human thrombin receptor have revealed a protein with seven transmembrane domains and a large extracellular amino-terminal extension. Thrombin cleaves within this extension, thereby creating a new receptor amino-terminus that functions as a tethered ligand and activates the receptor. A 14-amino acid peptide mimicking this new amino-terminus has been found to be a potent thrombin receptor activator as well as an effective agonist for platelet activation.

Formula: C₈₁H₁₁₈N₂₀O₂₃

Purity: 98.1%

Color and Shape: White

Molecular weight: 1739.95

Ref: 01-4031275

TRAP-14 trifluoroacetate salt

CAS: 137339-65-2

TRAP-14 is a conformationally restricted peptide that binds to the thrombin receptor. TRAP-14 also has a biocompatible polymer backbone that can be used in vivo as an implant. The TRAP-14 peptide has been shown to inhibit thrombin activity and inhibit the expression of basic fibroblast growth factor. In addition, this drug showed an ability to suppress autoimmune diseases in vivo by blocking Ca2+ release from the cytosol. This drug also showed inhibition of polymerase chain reaction (PCR) amplification and increased the specificity of PCR for DNA sequences containing polyvinyl disulfide bonds.

Formula: C₈₁H₁₁₈N₂₀O₂₃

Purity: Min. 95%

Molecular weight: 1,739.92 g/mol

Ref: 3D-FT110281

SER-PHE-LEU-LEU-ARG-ASN-PRO-ASN-ASP-LYS-TYR-GLU-PRO-PHE

CAS: 137339-65-2

Formula: C₈₁H₁₁₈N₂₀O₂₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 1739.9238

Ref: IN-DA009AWG

H-Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe-OH

CAS: 137339-65-2

Hypertension is a common condition that affects millions of people worldwide. It is characterized by an elevated blood pressure and the subsequent damage to the heart, kidneys, and other tissues. Metyrapone is a drug that inhibits the synthesis of corticosteroids from cholesterol in the adrenal glands. It was shown to reduce blood pressure in vivo by blocking the formation of cytosolic calcium and subsequent release of vasopressin. The use of metyrapone as a hypertension treatment has been limited due to its side effects on the liver. A new model system using basic fibroblasts (BF) instead of liver cells has been developed to study this drug's effects on hypertension without causing liver lesions. This model has proven successful for other drugs with similar biological properties, such as Hytrinol, which also blocks corticosteroid synthesis from cholesterol but does not cause liver lesions. The BF system can be used for testing new drugs that are selective for PAR1 receptors, which are

Formula: C₈₁H₁₁₈N₂₀O₂₃

Purity: Min. 95%

Molecular weight: 1,739.96 g/mol

Ref: 3D-PAR-3934-PI