CAS 1373431-65-2

Talazoparib tosylate

Description:

Talazoparib tosylate is a potent inhibitor of poly (ADP-ribose) polymerase (PARP), primarily used in cancer therapy, particularly for treating certain types of breast and ovarian cancers associated with BRCA mutations. This compound is characterized by its ability to interfere with DNA repair mechanisms, leading to the accumulation of DNA damage in cancer cells, ultimately promoting cell death. Talazoparib tosylate is typically administered in an oral form and exhibits high selectivity for PARP-1 and PARP-2 enzymes. Its chemical structure includes a tosylate moiety, which enhances its solubility and bioavailability. The substance is known for its favorable pharmacokinetic properties, including a long half-life, allowing for once-daily dosing. Additionally, it has been evaluated in clinical trials, demonstrating efficacy in patients with germline BRCA-mutated breast cancer. As with many targeted therapies, potential side effects may include hematological toxicities, fatigue, and gastrointestinal disturbances, necessitating careful monitoring during treatment. Overall, Talazoparib tosylate represents a significant advancement in precision oncology.

Synonyms:

• (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one tosylate

Talazoparib tosylate

CAS: 1373431-65-2

Talazoparib tosylate

Purity: ≥98%

Molecular weight: 552.55g/mol

Ref: 54-BUP05772

Talazoparib tosylate

CAS: 1373431-65-2

PF-3882845 is an MR antagonist that binds to the progesterone receptor (PR) and is used in the study of endocrine disorders and urogenital disorders.

Formula: C₂₆H₂₂F₂N₆O₄S

Purity: 99.79%

Color and Shape: Solid

Molecular weight: 552.55

Ref: TM-T16979

Talazoparib Tosylate

CAS: 1373431-65-2

Applications Talazoparib Tosylate is Quinoline derivative used for treating non-small cell lung cancer.
References Zhang, X., et al.: Faming Zhuanli Shenqing, (2020);

Formula: C₁₉H₁₄F₂N₆O·C₇H₈O₃S

Color and Shape: Off-White To Light Yellow

Molecular weight: 380.36 + 172.20

Ref: TR-T137340

Talazoparib tosylate

CAS: 1373431-65-2

Inhibitor of PARP polymerase

Formula: C₂₆H₂₂F₂N₆O₄S

Purity: Min. 95%

Molecular weight: 552.55 g/mol

Ref: 3D-FF164983

Talazoparib Tosylate

CAS: 1373431-65-2

Formula: C₁₉H₁₄F₂N₆OC₇H₈O₃S

Molecular weight: 380.4 : 172.2

Ref: ST-EA-CP-T84002