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CAS 137348-10-8

:

hypercalcemia of malignancy factor*fragment 107-1

Description:
Hypercalcemia of malignancy factor, specifically the fragment designated as 107-1, is a peptide associated with the pathological condition of hypercalcemia, often seen in malignancies. This fragment is derived from a larger protein that plays a role in calcium metabolism and is implicated in the disruption of normal calcium homeostasis in cancer patients. The CAS number 137348-10-8 identifies this specific fragment, which is characterized by its ability to influence osteoclastic activity, leading to increased bone resorption and elevated serum calcium levels. The peptide's structure and sequence contribute to its biological activity, making it a subject of interest in cancer research and potential therapeutic interventions. Its role in malignancy-related hypercalcemia highlights the complex interplay between tumor biology and mineral metabolism, underscoring the need for further studies to elucidate its mechanisms and potential applications in clinical settings.
Formula:C142H228N42O58
InChI:InChI=1/C142H228N42O58/c1-58(2)33-73(143)113(213)162-77(28-30-104(210)241-105(211)49-157-116(216)89(50-185)161-97(198)47-156-134(234)108(66(15)193)183-135(235)107(63(11)12)180-98(199)48-155-117(217)90(51-186)174-126(226)86(41-101(204)205)171-121(221)81(36-61(7)8)168-123(223)83(38-70-44-153-75-24-20-19-23-72(70)75)166-112(212)64(13)159-129(229)91(52-187)175-118(218)76(25-21-31-151-141(146)147)164-133(233)106(145)65(14)192)115(215)154-46-96(197)160-85(40-100(202)203)125(225)170-84(39-71-45-150-57-158-71)124(224)169-82(37-62(9)10)122(222)176-93(54-189)131(231)173-88(43-103(208)209)128(228)181-109(67(16)194)136(236)178-94(55-190)132(232)182-111(69(18)196)138(238)184-110(68(17)195)137(237)179-95(56-191)140(240)242-139(239)79(26-22-32-152-142(148)149)165-130(230)92(53-188)177-127(227)87(42-102(206)207)172-120(220)80(35-60(5)6)167-119(219)78(27-29-99(200)201)163-114(214)74(144)34-59(3)4/h19-20,23-24,44-45,57-69,71,73-74,76-95,106-111,153,185-196H,21-22,25-43,46-56,143-145H2,1-18H3,(H,154,215)(H,155,217)(H,156,234)(H,157,216)(H,159,229)(H,160,197)(H,161,198)(H,162,213)(H,163,214)(H,164,233)(H,165,230)(H,166,212)(H,167,219)(H,168,223)(H,169,224)(H,170,225)(H,171,221)(H,172,220)(H,173,231)(H,174,226)(H,175,218)(H,176,222)(H,177,227)(H,178,236)(H,179,237)(H,180,199)(H,181,228)(H,182,232)(H,183,235)(H,184,238)(H,200,201)(H,202,203)(H,204,205)(H,206,207)(H,208,209)(H4,146,147,151)(H4,148,149,152)/t64-,65+,66+,67+,68+,69+,71?,73-,74-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,106-,107-,108-,109-,110-,111-/m0/s1
Synonyms:
  • Parathyroid hormone-related protein-(107-139)
  • Pthrp (107-139)
  • L-Arginine, L-threonyl-L-arginyl-L-seryl-L-alanyl-L-tryptophyl-L-leucyl-L-alpha-aspartyl-L-serylglycyl-L-valyl-L-threonylglycyl-L-serylglycyl-L-leucyl-L-alpha-glutamylglycyl-L-alpha-aspartyl-L-histidyl-L-leucyl-L-seryl-L-alpha-aspartyl-L-thronyl-L-seryl-L-threonyl-L-threonyl-L-seryl-L-leucyl-L-alpha-glutamyl-L-leucyl-L-alpha-aspartyl-L-seryl-
  • Hypercalcemia Of Malignancy Factor (107-139) (Human)
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Found 2 products.
  • Osteostatin (human)
    Bachem
    + Info

    Osteostatin (human)

    CAS:
    The carboxyl-terminal fragment of pTHrP, TRSAWLDSGVTGSGLEGDHLSDTSTTSLELDSR, is a potent inhibitor of osteoclastic bone resorption. It is suggested that this product acts directly on osteoclasts.
    Formula:C142H228N42O58
    Color and Shape:White Powder
    Molecular weight:3451.62

    Ref: 01-4031194

    1mg
    766.00€
    0.5mg
    432.00€
  • Osteostatin (human) trifluoroacetate salt
    Biosynth
    + Info

    Osteostatin (human) trifluoroacetate salt

    CAS:
    <p>Osteostatin is a recombinant human protein that inhibits bone growth by binding to and neutralizing the effect of forskolin. Osteostatin also has an inhibitory effect on cancer cells, as it inhibits mitochondrial pathways and prevents the activation of factor receptors. Osteostatin blocks the synthesis of cAMP, which is necessary for cell proliferation in cancer cells. The inhibition of cAMP levels leads to a decrease in the production of proteins that stimulate bone growth, such as runx2.</p>
    Formula:C142H228N42O58
    Purity:Min. 95%
    Molecular weight:3,451.58 g/mol

    Ref: 3D-FO108927

    1mg
    1,088.00€
    2mg
    1,878.00€
    500µg
    860.00€