CAS 137361-05-8

Nω-Propyl-L-arginine

Description:

Nω-Propyl-L-arginine is a synthetic amino acid derivative of arginine, characterized by the presence of a propyl group at the nitrogen atom of the guanidino side chain. This modification enhances its solubility and bioavailability compared to its parent compound, L-arginine. It is often utilized in biochemical research, particularly in studies involving nitric oxide synthesis and signaling pathways, as it can act as a substrate for nitric oxide synthase. The compound exhibits properties typical of amino acids, including the ability to form hydrogen bonds and participate in ionic interactions, which are crucial for its biological activity. Nω-Propyl-L-arginine is also known for its potential role in modulating vascular function and has been investigated for its therapeutic implications in cardiovascular diseases. Its molecular structure includes a chiral center, making it optically active, and it is typically handled in a laboratory setting with standard safety precautions due to its biochemical activity.

Formula: C₉H₂₀N₄O₂

InChI: InChI=1S/C9H20N4O2/c1-2-5-12-9(11)13-6-3-4-7(10)8(14)15/h7H,2-6,10H2,1H3,(H,14,15)(H3,11,12,13)/t7-/m0/s1

InChI key: InChIKey=AOMXURITGZJPKB-ZETCQYMHSA-N

SMILES: N(CCC[C@@H](C(O)=O)N)C(NCCC)=N

Synonyms:

• 2(S)-2-Amino-5-(N-Propylguanidino)Pentanoic Acid
• <span class="text-smallcaps">L</span>-Ornithine, N⁵-[imino(propylamino)methyl]-
• L-N5-(1-Imino(Propylamino))Methyl-Ornithine
• L-N5-(1-Imino-9-Propylamino-O-Methyl)Orinthine
• N-Pla
• N5-[Imino(Propylamino)Methyl]-L-Ornithine
• N⁵-[Imino(propylamino)methyl]-<span class="text-smallcaps">L</span>-ornithine
• N^G-Propyl-<span class="text-smallcaps">L</span>-arginine
• N^ω-Propyl-<span class="text-smallcaps">L</span>-arginine
• Ng-Propyl-L-Arginine
• Nw-Propyl-L-Arginine
• N~5~-(N'-propylcarbamimidoyl)-L-ornithine
• L-Ornithine, N5-[imino(propylamino)methyl]-

(S)-2-Amino-5-(3-propylguanidino)pentanoic acid

CAS: 137361-05-8

Formula: C₉H₂₀N₄O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 216.2807

Ref: IN-DA00135V

N-ω-Propyl-L-Arginine

CAS: 137361-05-8

Molecular weight: 216.28

Ref: 7W-GM0713

Nω-Propyl-L-arginine

CAS: 137361-05-8

Nω-Propyl-L-arginine, a powerful and specific inhibitor of neuronal nitric oxide synthase (nNOS), effectively inhibits nNOS with a Ki of 57 nM.

Formula: C₉H₂₀N₄O₂

Color and Shape: Solid

Molecular weight: 216.28

Ref: TM-T38786

N-ω-Propyl-L-arginine

CAS: 137361-05-8

Neuronal selective nitric oxide synthase inhibitor

Formula: C₉H₂₀N₄O₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 216.28 g/mol

Ref: 3D-FP27236

N-ω-Propyl-L-arginine - Bio-X ™

CAS: 137361-05-8

N-ω-Propyl-L-arginine is a selective inhibitor of neuronal nitric oxide synthase (nNOS). This enzyme is involved in the production of nitric oxide, which plays important roles in various physiological and pathological processes in the body. N-ω-Propyl-L-arginine selectively inhibits nNOS, preventing the conversion of L-arginine to nitric oxide. This makes it a useful tool for studying the role of nNOS in various Life Sciences fields, such as neuroscience and cardiovascular research. It can also be used as an enzyme modulator or ligand in drug discovery studies targeting nNOS.
N-ω-Propyl-L-arginine is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₉H₂₀N₄O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 216.28 g/mol

Ref: 3D-FP27248

Nω-Propyl-L-Arginine

Controlled Product

CAS: 137361-05-8

Stability Very Hygroscopic
Applications Nω-Propyl-L-Arginine is a neuronal selective nitric oxide synthase inhibitor (1) and a highly selective competitive inhibitor and inactivator of all three isoforms of NOS (2,3).
References (1) Klamer, D., et al.: Eur. J. Pharmacol. (2004) 503: 103-107(2) Marletta, M.A.: J. Med. Chem., 37(13), 1899 (1994)(3) Zhang, H.Q., et al.: J. Med. Chem., 40, 3869 (1997)

Formula: C₉H₂₀N₄O₂

Color and Shape: Neat

Molecular weight: 216.28

Ref: TR-P835000