CAS 137417-08-4

Dihydrexidine hydrochloride

Description:

Dihydrexidine hydrochloride is a synthetic compound primarily known for its role as a selective dopamine D1 receptor agonist. It is characterized by its ability to activate dopamine receptors, which are crucial in various neurological processes, including mood regulation and motor control. The compound is often studied in the context of neuropharmacology and has potential implications for treating conditions such as Parkinson's disease and schizophrenia. Dihydrexidine hydrochloride is typically administered in a hydrochloride salt form, enhancing its solubility and stability in aqueous solutions. Its chemical structure features a bicyclic framework, which contributes to its receptor selectivity and pharmacological profile. As with many pharmacologically active substances, understanding its pharmacokinetics, including absorption, distribution, metabolism, and excretion, is essential for evaluating its therapeutic potential and safety. Research continues to explore its effects and mechanisms of action, making it a subject of interest in both academic and clinical settings.

Formula: C₁₇H₁₇NO₂·ClH

InChI: InChI=1/C17H17NO2.ClH/c19-15-7-10-5-6-14-17(13(10)8-16(15)20)12-4-2-1-3-11(12)9-18-14;/h1-4,7-8,14,17-20H,5-6,9H2;1H/t14-,17-;/s2

InChI key: InChIKey=IJYUPBNUPIRQEP-PROMZIARNA-N

SMILES: OC=1C=C2[C@]3(C=4C(CN[C@@]3(CCC2=CC1O)[H])=CC=CC4)[H].Cl

Synonyms:

• Benzo[a]phenanthridine-10,11-diol, 5,6,6a,7,8,12b-hexahydro-, hydrochloride, trans-
• Benzo[a]phenanthridine-10,11-diol, 5,6,6a,7,8,12b-hexahydro-, hydrochloride (1:1), (6aR,12bS)-rel-
• Dihydrexidine hydrochloride
• Benzo[a]phenanthridine-10,11-diol, 5,6,6a,7,8,12b-hexahydro-, hydrochloride, (6aR,12bS)-rel-

Dihydrexidine hydrochloride

CAS: 137417-08-4

Dihydrexidine hydrochloride is a dopamine transport inhibitor that binds to the dopamine transporter. This drug has been shown to bind to the d2 receptor and increase levels of dopamine in the brain, which may have a beneficial effect on cognition. Dihydrexidine hydrochloride also modulates catechol-o-methyltransferase and thereby prevents the breakdown of catecholamines such as dopamine. It has been used for depression and opioid analgesia. Dihydrexidine hydrochloride is a prodrug that undergoes rapid metabolism by esterases or glucuronidases to dihydrexidine, its active form. Dihydrexidine hydrochloride has been shown to bind specifically to an antigen present in maleate-treated rats, but not in control rats, suggesting that there is a reaction between these two substances. The phosphate ions are required for this reaction.br>br>

Formula: C₁₇H₁₈ClNO₂

Purity: Min. 95%

Molecular weight: 303.8 g/mol

Ref: 3D-MFA41708