CAS 1374640-70-6

CO-1686

Description:

CO-1686, also known as Osimertinib, is a selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, primarily used in the treatment of non-small cell lung cancer (NSCLC) with specific mutations. It is characterized by its ability to target both activating mutations and the T790M resistance mutation in the EGFR gene, making it effective in patients who have developed resistance to earlier EGFR inhibitors. The compound exhibits high selectivity for mutant EGFR over wild-type EGFR, which helps to minimize off-target effects and enhance therapeutic efficacy. CO-1686 is typically administered orally and has a favorable pharmacokinetic profile, allowing for once-daily dosing. Its mechanism of action involves the inhibition of downstream signaling pathways that promote tumor growth and survival. Additionally, CO-1686 has been associated with a manageable safety profile, with common adverse effects including diarrhea, rash, and fatigue. Overall, CO-1686 represents a significant advancement in targeted cancer therapy, particularly for patients with specific EGFR mutations.

Formula: C₂₇H₂₈F₃N₇O₃

Rociletinib

CAS: 1374640-70-6

Rociletinib (CNX-419) is an orally available small molecule, irreversible inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplastic

Formula: C₂₇H₂₈F₃N₇O₃

Purity: 98.52% - 99.25%

Color and Shape: Solid

Molecular weight: 555.55

Ref: TM-T2369

N-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide

CAS: 1374640-70-6

Formula: C₂₇H₂₈F₃N₇O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 555.5515

Ref: IN-DA0039L5

Rociletinib

CAS: 1374640-70-6

Rociletinib

Purity: ≥98%

Molecular weight: 555.55g/mol

Ref: 54-BUP10582

N-(3-((2-((4-(4-Acetylpiperazin-1-Yl)-2-Methoxyphenyl)Amino)-5-(Trifluoromethyl)Pyrimidin-4-Yl)Amino)Phenyl)Acrylamide

CAS: 1374640-70-6

N-(3-((2-((4-(4-Acetylpiperazin-1-Yl)-2-Methoxyphenyl)Amino)-5-(Trifluoromethyl)Pyrimidin-4-Yl)Amino)Phenyl)Acrylamide

Purity: 98%

Molecular weight: 555.55g/mol

Ref: 54-PC108901

Rociletinib

CAS: 1374640-70-6

Purity: 99%

Molecular weight: 555.56201171875

Ref: 10-F862507

CO 1686

Controlled Product

CAS: 1374640-70-6

Applications CO 1686 is seen as an irreversible epidermal growth factor receptor (EFGR1) kinase inhibitor.
References Walter, A. et al.: Cancer Disc., 21, 3 (2013);

Formula: C₂₇H₂₈F₃N₇O₃

Color and Shape: Neat

Molecular weight: 555.55

Ref: TR-C633000

Rociletinib

CAS: 1374640-70-6

Inhibitor of EGFR and T790M-mutated EGFR

Formula: C₂₇H₂₈F₃N₇O₃

Purity: Min. 95%

Molecular weight: 555.55 g/mol

Ref: 3D-FA103658