CAS 1374996-60-7

6H-INDENO[1,2-E]TETRAZOLO[1,5-B][1,2,4]TRIAZIN-6-ONE

Description:

6H-Indeno[1,2-e]tetrazolo[1,5-b][1,2,4]triazine-6-one is a heterocyclic compound characterized by its complex fused ring structure, which incorporates both indeno and tetrazolo-triazine moieties. This compound features a unique arrangement of nitrogen and carbon atoms, contributing to its potential biological activity and chemical reactivity. The presence of multiple nitrogen atoms within the ring system often imparts interesting electronic properties, making it a candidate for various applications in pharmaceuticals and materials science. The compound is typically synthesized through multi-step organic reactions, which may involve cyclization and functionalization processes. Its solubility and stability can vary depending on the substituents present on the rings, influencing its behavior in different solvents and conditions. As a relatively novel compound, research into its properties, including its reactivity, potential applications, and interactions with biological systems, is ongoing, highlighting its significance in the field of medicinal chemistry and materials development.

Formula: C₂₀H₈N₁₂O₂

Synonyms:

• 6H-INDENO[1,2-E]TETRAZOLO[1,5-B][1,2,4]TRIAZIN-6-ONE
• 10H-Indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one (1:1)
• ZERENEX E/6026591

KP372-1

Controlled Product

CAS: 1374996-60-7

Applications KP372-1 is a specific Akt inhibitor that demonstrates at least 10-fold selectivity against a panel of additional kinase targets, including CDK1, ERK1, GSK3β, LCK, MEK1, PKA, PKC, and S6K. By blocking Akt signaling, KP372-1 has been shown to inhibit proliferation and to induce apoptosis of thyroid cancer cells.
References Zeng, Z., et al.: Cancer Res, 66, 3737-3746 (2006); Mandal, M., et al.: Br. J. Cancer, BJC, 92, 1899-1905 (2005)

Formula: C₁₀H₄N₆O·C₁₀H₄N₆O

Color and Shape: Neat

Molecular weight: 448.36

Ref: TR-K658800

KP372-1

CAS: 1374996-60-7

KP372-1 is a selective inhibitor that is synthetically derived. This compound functions by targeting and interfering with specific signaling pathways involved in cell growth and survival. Its inhibitory action primarily affects pathways such as PI3K/Akt, which are integral to the processes of cellular proliferation and apoptosis.

Formula: C₂₀H₈N₁₂O₂

Purity: Min. 95%

Molecular weight: 448.4 g/mol

Ref: 3D-ZEC99660

KP372-1

CAS: 1374996-60-7

KP372-1, an Akt inhibitor, blocks PI3K signaling, arrests cell growth, and triggers apoptosis in head/neck squamous cell carcinoma.

Formula: C₂₀H₈N₁₂O₂

Color and Shape: Solid

Molecular weight: 448.36

Ref: TM-T21964