CAS 137530-41-7: (+)-2′-Deoxy-3′-thia-5-fluorocytidine

Description: (+)-2′-Deoxy-3′-thia-5-fluorocytidine, with the CAS number 137530-41-7, is a synthetic nucleoside analog that incorporates sulfur and fluorine into its structure, modifying the natural nucleoside cytidine. This compound features a thioether linkage at the 3′ position and a fluorine atom at the 5′ position, which enhances its stability and alters its biological activity. It is primarily studied for its potential antiviral and anticancer properties, as it can interfere with nucleic acid synthesis. The presence of the fluorine atom can enhance the compound's affinity for viral polymerases, making it a candidate for therapeutic applications against certain viral infections. Additionally, the thioether modification may contribute to its resistance to enzymatic degradation. The compound is typically characterized by its molecular formula, stereochemistry, and specific interactions with biological targets, which are crucial for understanding its pharmacological profile. Overall, (+)-2′-Deoxy-3′-thia-5-fluorocytidine represents a significant area of research in medicinal chemistry and drug development.

Formula: C₈H₁₀FN₃O₃S

InChI: InChI=1S/C8H10FN3O3S/c9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5/h1,5-6,13H,2-3H2,(H2,10,11,14)/t5-,6+/m1/s1

InChI key: InChIKey=XQSPYNMVSIKCOC-RITPCOANSA-N

SMILES: O=C1N=C(N)C(F)=CN1C2OC(SC2)CO

Synonyms:

• (+)-2′-Deoxy-3′-thia-5-fluorocytidine
• (+)-Ftc
• 1,3-Oxathiolane, 2(1H)-pyrimidinone deriv.
• 1-(2-(Hydroxymethyl)oxathiolan-5-yl)-5-fluorocytosine
• 2',3',5-Ftc
• 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, rel-
• 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, cis-
• 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-
• 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-, (2S-cis)-
• 3'-Thia-2'.3'-dideoxy-5-fluorocytidine
• 4-Amino-5-fluoro-1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
• 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one
• 4-amino-5-fluoro-1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one
• 5-Fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine
• 524W91
• Bw 524W91
• RCV
• Racivir
• 2',3'-Dideoxy-5-fluoro-3'-thiacytidine

Emtricitabine Enantiomer (4-amino-5-fluoro-1-((2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one; 5-Fluoro-1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine)

CAS: 137530-41-7

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

• Formula: C₈H₁₀FN₃O₃S
• Color and Shape: Off-White Solid
• Molecular weight: 247.04269

2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-[(2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-

CAS: 137530-41-7

• Formula: C₈H₁₀FN₃O₃S
• Purity: 95%
• Color and Shape: Solid
• Molecular weight: 247.2467

Emtricitabine Enantiomer

CAS: 137530-41-7

• Formula: C₈H₁₀FN₃O₃S
• Color and Shape: White To Off-White Solid
• Molecular weight: 247.24

(+)-Emtricitabine

CAS: 137530-41-7

Emtricitabine IP Impurity D

CAS: 137530-41-7

• Formula: C₈H₁₀FN₃O₃S
• Molecular weight: 247.25

ent-Emtricitabine

CAS: 137530-41-7

Stability Hygroscopic Applications A reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, …

• Formula: C₈H₁₀FN₃O₃S
• Color and Shape: Neat
• Molecular weight: 247.25

(+)-Emtricitabine

CAS: 137530-41-7

Emtricitabine is a synthetic nucleoside analog of cytidine. It is used in the treatment of …

• Formula: C₈H₁₀FN₃O₃S
• Purity: Min. 95%
• Molecular weight: 247.25 g/mol