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CAS 137592-45-1

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Bisindolylmaleimide II

Description:
Bisindolylmaleimide II, with the CAS number 137592-45-1, is a synthetic compound known for its role as a selective inhibitor of protein kinase C (PKC). This compound features a unique structure that includes two indole rings connected by a maleimide moiety, which contributes to its biological activity. It is typically characterized by its solid state at room temperature and is soluble in organic solvents such as dimethyl sulfoxide (DMSO) and ethanol, but has limited solubility in water. Bisindolylmaleimide II is often utilized in biochemical research to study signal transduction pathways, particularly those involving PKC, which plays a critical role in various cellular processes including proliferation, differentiation, and apoptosis. The compound's specificity for different PKC isoforms makes it a valuable tool in pharmacological studies and drug development. Additionally, it has been investigated for potential therapeutic applications in cancer and other diseases where PKC is implicated. Safety data should be reviewed before handling, as with any chemical substance.
Formula:C27H26N4O2
InChI:InChI=1S/C27H26N4O2/c1-30-13-6-7-17(30)12-14-31-16-21(19-9-3-5-11-23(19)31)25-24(26(32)29-27(25)33)20-15-28-22-10-4-2-8-18(20)22/h2-5,8-11,15-17,28H,6-7,12-14H2,1H3,(H,29,32,33)
InChI key:InChIKey=LBFDERUQORUFIN-UHFFFAOYSA-N
SMILES:O=C1C(=C(C(=O)N1)C=2C=3C(NC2)=CC=CC3)C=4C=5C(N(CCC6N(C)CCC6)C4)=CC=CC5
Synonyms:
  • 1H-Pyrrole-2,5-dione, 3-(1H-indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-
  • 3-(1H-Indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione
  • Bisindolylmaleimide II
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