CAS 137593-52-3

L-Methioninamide,L-lysyl-L-a-aspartyl-L-seryl-L-phenylalanyl-L-valyl-(aS,3R)-3-amino-a-(2-methylpropyl)-2-oxo-1-pyrrolidineacetyl-

Description:

L-Methioninamide, L-lysyl-L-a-aspartyl-L-seryl-L-phenylalanyl-L-valyl-(αS,3R)-3-amino-α-(2-methylpropyl)-2-oxo-1-pyrrolidineacetyl- is a complex peptide compound characterized by its specific sequence of amino acids and a unique pyrrolidine ring structure. This compound features a combination of hydrophilic and hydrophobic amino acids, which contributes to its potential biological activity and solubility properties. The presence of the methionine amide group may enhance its stability and bioavailability. The stereochemistry indicated by the (αS,3R) notation suggests specific spatial arrangements of atoms, which can significantly influence the compound's interactions with biological targets. Such peptides are often studied for their roles in biological processes, potential therapeutic applications, and as models for understanding protein folding and function. The CAS number 137593-52-3 serves as a unique identifier for this substance, facilitating its identification in chemical databases and literature. Overall, this compound exemplifies the complexity and diversity of peptide chemistry, with implications for research in biochemistry and pharmacology.

Formula: C₄₂H₆₈N₁₀O₁₁S

Synonyms:

• L-Valinamide,L-lysyl-L-a-aspartyl-L-seryl-L-phenylalanyl-N-[1-[1-[[[1-(aminocarbonyl)-3-(methylthio)propyl]amino]carbonyl]-3-methylbutyl]-2-oxo-3-pyrrolidinyl]-,[3R-[1[S*(S*)],3R*]]-
• Gr 64349

GR 64349

CAS: 137593-52-3

Formula: C₄₂H₆₈N₁₀O₁₁S

Molecular weight: 921.11

Ref: 7W-GK6535

GR 64349

CAS: 137593-52-3

Potent NK2 agonist, EC50=3.7 nM in rat colon; >1000x selectivity over NK1, >300x over NK3; effective in vivo.

Formula: C₄₂H₆₈N₁₀O₁₁S

Purity: 98%

Color and Shape: Solid

Molecular weight: 921.12

Ref: TM-TP2023

GR 64349

CAS: 137593-52-3

GR 64349 is a non-selective cation channel blocker that binds to the voltage-dependent calcium channels in mammalian cells. It inhibits the influx of calcium ions into these cells, which may lead to an antiemetic effect by reducing the release of acetylcholine and histamine from nerve terminals in the brain stem. GR 64349 has also been shown to have an inhibitory effect on autoimmune diseases, such as psoriasis, rheumatoid arthritis, and multiple sclerosis. Clinical trials are underway for GR 64349 as a potential treatment for bladder dysfunction in patients with spinal cord injury.

Formula: C₄₂H₆₈N₁₀O₁₁S

Purity: Min. 95%

Molecular weight: 921.12 g/mol

Ref: 3D-MFA59352