CAS 137766-83-7

Ac4GlcNAcF3

Description:

Ac4GlcNAcF3, also known as 2-acetamido-2-deoxy-α-D-glucopyranosyl fluoride, is a synthetic carbohydrate derivative that features a glucosamine backbone modified with acetyl groups and a fluorinated moiety. This compound is characterized by its structural components, which include an acetylated amine group and a fluorine atom, contributing to its unique chemical properties. Ac4GlcNAcF3 is often utilized in biochemical research, particularly in studies involving glycosylation and carbohydrate-protein interactions. The presence of the fluorine atom can enhance the stability and reactivity of the molecule, making it a valuable tool in the synthesis of glycosylated compounds. Additionally, its acetyl groups can influence solubility and reactivity, allowing for various applications in medicinal chemistry and glycoengineering. As a synthetic analog, it serves as a substrate or inhibitor in enzymatic reactions involving glycosyltransferases, providing insights into glycan biosynthesis and function. Overall, Ac4GlcNAcF3 is a significant compound in the field of carbohydrate chemistry and biochemistry.

Formula: C₁₆H₂₀F₃NO₁₀

Synonyms:

• (2R,3S,4R,5R)-3,4,6-triacetoxy-5-[(2,2,2-trifluoroacetyl)amino]tetrahydropyran-2-yl]methyl acetate
• D-Glucopyranose, 2-deoxy-2-[(2,2,2-trifluoroacetyl)amino]-, 1,3,4,6-tetraacetate
• 1,3,4,6-tetra-O-acetyl-2-deoxy-2-trifluoroacetylamino-D-glucopyranose
• Ac4GlcNAcF3

D-Glucopyranose, 2-deoxy-2-[(trifluoroacetyl)amino]-,1,3,4,6-tetraacetate

CAS: 137766-83-7

Formula: C₁₆H₂₀F₃NO₁₀

Purity: 95%

Color and Shape: Solid

Molecular weight: 443.3259

Ref: IN-DA0220AJ

(3R,4R,5S,6R)-6-(Acetoxymethyl)-3-(2,2,2-trifluoroacetamido)tetrahydro-2H-pyran-2,4,5-triyl triacetate

CAS: 137766-83-7

(3R,4R,5S,6R)-6-(Acetoxymethyl)-3-(2,2,2-trifluoroacetamido)tetrahydro-2H-pyran-2,4,5-triyl triacetate

Purity: 95%

Molecular weight: 443.33g/mol

Ref: 54-PC1002718

1,3,4,6-Tetra-O-acetyl-2-deoxy-2-(2,2,2-trifluoroacetylamino)-D-glucopyranoside

CAS: 137766-83-7

Potent, selective and cell-permeable tool for modulation of O-GlcNAcylation. Ac4GlcNAcF3 is a dual modulator of O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Ac4GlcNAcF3 perturbates the GlcNAc cycling as OGT can incorporate GlcNAcF3 onto proteins but subsequently, it cannot be removed by OGA. In a mouse embryogenic fibroblast cell line, Ac4GlcNAcF3 increased the level of protein O-GlcNAcylation.

Formula: C₁₆H₂₀F₃NO₁₀

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 443.33 g/mol

Ref: 3D-BA170096