CAS 137813-35-5

CYCLO(ARG-GLY-ASP-D-PHE-VAL)

Description:

CYCLO(ARG-GLY-ASP-D-PHE-VAL), with the CAS number 137813-35-5, is a cyclic peptide composed of five amino acids: arginine (Arg), glycine (Gly), aspartic acid (Asp), D-phenylalanine (D-Phe), and valine (Val). The cyclic structure is formed by linking the terminal amino and carboxyl groups, which enhances its stability compared to linear peptides. This compound exhibits characteristics typical of peptides, such as the ability to interact with biological receptors and enzymes, making it of interest in pharmaceutical research, particularly in drug design and development. Its specific sequence and cyclic nature may contribute to unique biological activities, including potential roles in modulating cellular processes or serving as a scaffold for drug delivery. Additionally, the presence of D-amino acids, like D-Phe, can influence the peptide's resistance to enzymatic degradation, further enhancing its therapeutic potential. Overall, CYCLO(ARG-GLY-ASP-D-PHE-VAL) represents a valuable compound in the field of medicinal chemistry and peptide research.

Formula: C₂₆H₃₈N₈O₇

Synonyms:

• Cyclo(Rgdd-Fv)
• Rgdfv Peptide, Cyclic

Cyclo(-Arg-Gly-Asp-D-Phe-Val)

CAS: 137813-35-5

c(RGDfV) is a potent inhibitor of cell adhesion. It inhibited tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats provided the first evidence of its utility in the amelioration of ischemic acute renal failure. c(RGDfV) inhibited tubular obstruction by preventing cell-cell adhesion. Hammes et al. showed that the cyclopeptide can also be used to prevent retinal neovascularization. c(RGDfV) binds to αvβ3 receptors.

Formula: C₂₆H₃₈N₈O₇

Purity: 96.9%

Color and Shape: White Lyophilisate

Molecular weight: 574.64

Ref: 01-4026200

Cyclo(Arg-Gly-Asp-D-Phe-Val)

CAS: 137813-35-5

Cyclo(Arg-Gly-Asp-D-Phe-Val) is a peptide inhibitor of protein interactions. It binds to the ligand binding site of receptor and inhibits the activation of this receptor. Cyclo(Arg-Gly-Asp-D-Phe-Val) also binds to antibodies and can be used as a research tool for identifying antibody targets.

Formula: C₂₆H₃₈N₈O₇•CH₃COOH•2H₂O

Purity: Min. 95%

Molecular weight: 670.91 g/mol

Ref: 3D-ICA-4304-V

Cyclo(Arg-Gly-Asp-D-Phe-Val)

CAS: 137813-35-5

Cyclo(Arg-Gly-Asp-D-Phe-Val) is a cyclic peptide that inhibits the activity of surface glycoprotein enzymes. It has shown to be effective against malignant brain tumor cells and has anti-angiogenic effects. Cyclo(Arg-Gly-Asp-D-Phe-Val) also inhibits integrin receptor function by binding to the αVβ3 or αVβ5 integrin, which may be useful for biomarker identification. This compound is potent as an antagonist to epidermal growth factor (EGF), which may have potential use in treating benign prostatic hyperplasia.

Formula: C₂₆H₃₈N₈O₇

Purity: Min. 95%

Molecular weight: 574.63 g/mol

Ref: 3D-ICA-4304

Cyclo(-Arg-Gly-Asp-D-Phe-Val) trifluoroacetate salt

CAS: 137813-35-5

Cyclo(-Arg-Gly-Asp-D-Phe-Val) trifluoroacetate salt is a basic fibroblast growth factor that has been shown to have proliferative effects on diabetic retinopathy and ocular neovascularization. It binds to integrin receptors on the surface of cells, which are involved in cell adhesion. Cyclo(-Arg-Gly-Asp-D-Phe-Val) trifluoroacetate salt also has antiangiogenic effects and blocks the angiogenesis process by inhibiting the production of epidermal growth factor (EGF). This drug may be useful for treating certain types of cancer such as malignant brain tumors or neuroblastomas, because it can cause neuronal death. Cyclo(-Arg-Gly-Asp-D-Phe-Val) trifluoroacetate salt is a cyclic peptide with a reactive amino acid side chain.

Formula: C₂₆H₃₈N₈O₇

Purity: Min. 95%

Molecular weight: 574.63 g/mol

Ref: 3D-FC108714