CAS 137862-87-4

Valsartan

Description:

Valsartan is an angiotensin II receptor blocker (ARB) primarily used in the treatment of hypertension and heart failure. Its chemical formula is C24H29N5O3, and it features a biphenyl structure with a tetrazole ring, which contributes to its pharmacological activity. Valsartan works by inhibiting the action of angiotensin II, a hormone that causes blood vessels to constrict, thereby promoting vasodilation and reducing blood pressure. The substance is typically administered orally and is known for its relatively long half-life, allowing for once-daily dosing. Valsartan is generally well-tolerated, but like all medications, it may have side effects, including dizziness, fatigue, and potential renal impairment. It is contraindicated in certain populations, such as pregnant women, due to the risk of fetal harm. The compound is also subject to various regulatory standards to ensure its safety and efficacy in clinical use.

Formula: C₂₄H₂₉N₅O₃

InChI: InChI=1/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m1/s1

SMILES: CCCCC(=O)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)[C@H](C(C)C)C(=O)O

Synonyms:

• 3-Methyl-2-[Pentanoyl-[[4-[2-(2H-Tetrazol-5-Yl)Phenyl]Phenyl]Methyl]Amino]-Butanoic Acid
• N-pentanoyl-N-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}valine
• N-pentanoyl-N-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valine
• N-pentanoyl-N-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-D-valine
• D-Valine, N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
• Valsartan(Diovan)
• N-(1-Oxopentyl)-N-((2'-(1H-Tetrazol-5-Yl)(1,1'-Biphenyl)-3-Yl)Methyl)-L-Valine

Valsartan Related Compound A (N-Valeryl-N-{[2'-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}D-valine)

CAS: 137862-87-4

Aromatic or modified aromatic heterocyclic compounds withnitrogen hetero-atom(s) only nesoi

Formula: C₂₄H₂₉N₅O₃

Color and Shape: Off-White Powder

Molecular weight: 435.22704

Ref: 45-1708773

D-Valine, N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-

CAS: 137862-87-4

Formula: C₂₄H₂₉N₅O₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 435.5188

Ref: IN-DA0013YX

Valsartan EP Impurity A (Valsartan USP Related Compound A, ent-Valsartan)

CAS: 137862-87-4

Formula: C₂₄H₂₉N₅O₃

Color and Shape: White To Off-White Solid

Molecular weight: 435.53

Ref: 4Z-V-025

(2R)-3-Methyl-2-[pentanoyl[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]amino]butanoic Acid (Valsartan (R)-Enantiomer)

CAS: 137862-87-4

Color and Shape: Neat

Ref: 86-MM0487.02

ent-Valsartan

CAS: 137862-87-4

Impurity Valsartan USP Related Compound A
Applications ent-Valsartan (Valsartan USP Related Compound A) is the (R)-enantiomer of Valsartan (V095750).
References Corea, L., et al.: Clin. Pharmacol. Ther., 60, 341 (1996), Satana, E;., et al.: J. Pharm. Biomed. Anal., 25, 1009 (2001), Sironi, L., et al.: Hypertension, 37, 961 (2001),

Formula: C₂₄H₂₉N₅O₃

Color and Shape: White

Molecular weight: 435.52

Ref: TR-V095755

(R)-2-(N-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic acid

CAS: 137862-87-4

Purity: 95.0%

Molecular weight: 435.52801513671875

Ref: 10-F093756

Valsartan EP Impurity A

CAS: 137862-87-4

Formula: C₂₄H₂₉N₅O₃

Molecular weight: 435.52

Ref: ST-EA-CP-V3001

N-(1-Oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-D-valine

CAS: 137862-87-4

N-(1-Oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-D-valine is a potent and selective inhibitor of the enzyme lipase. It prevents the hydrolysis of triglycerides by competitively binding to the active site of lipase. This inhibition leads to an increase in serum levels of triglycerides, which are associated with cardiometabolic risk factors. Novartis developed this drug as an alternative to sacubitril/valsartan, which is used for the treatment of heart failure. The pharmacokinetics and pharmacodynamics of this drug are similar to those of sacubitril/valsartan. N-(1-Oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-D-

Formula: C₂₄H₂₉N₅O₃

Purity: Min. 95%

Color and Shape: White To Off-White Solid

Molecular weight: 435.52 g/mol

Ref: 3D-IO22697