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CAS 137882-98-5

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Abitesartan

Description:
Abitesartan is an angiotensin II receptor antagonist primarily used in the treatment of hypertension. It belongs to the class of medications known as sartans, which work by blocking the action of angiotensin II, a hormone that causes blood vessels to constrict, thereby lowering blood pressure. The chemical structure of Abitesartan includes a biphenyl group and a carboxylic acid moiety, contributing to its pharmacological activity. It is typically administered orally and exhibits a favorable pharmacokinetic profile, including good absorption and a relatively long half-life, allowing for once-daily dosing. Common side effects may include dizziness, fatigue, and gastrointestinal disturbances, although it is generally well-tolerated. As with other medications in its class, Abitesartan may also have protective effects on renal function, making it beneficial for patients with certain comorbidities. It is important to monitor renal function and electrolyte levels during treatment, particularly in patients with pre-existing conditions. Overall, Abitesartan represents a valuable option in the management of hypertension and related cardiovascular conditions.
Formula:C26H31N5O3
InChI:InChI=1S/C26H31N5O3/c1-2-3-10-23(32)31(18-26(25(33)34)15-6-7-16-26)17-19-11-13-20(14-12-19)21-8-4-5-9-22(21)24-27-29-30-28-24/h4-5,8-9,11-14H,2-3,6-7,10,15-18H2,1H3,(H,33,34)(H,27,28,29,30)
InChI key:InChIKey=ZUMPSVPHCDJCMD-UHFFFAOYSA-N
SMILES:C(N(CC1=CC=C(C=C1)C2=C(C=CC=C2)C=3NN=NN3)C(CCCC)=O)C4(C(O)=O)CCCC4
Synonyms:
  • 1-[[(1-Oxopentyl)[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]amino]methyl]cyclopentanecarboxylic acid
  • Cyclopentanecarboxylic acid, 1-[[(1-oxopentyl)[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]amino]methyl]-
  • Cyclopentanecarboxylic acid, 1-[[(1-oxopentyl)[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]amino]methyl]-
  • Abitesartan
  • 1-[[N-[p-(o-1H-Tetrazol-5-ylphenyl)benzyl]valeramido]methyl]-1-cyclopentanecarboxylic acid
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