CAS 137982-91-3

7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one

Description:

7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one, with the CAS number 137982-91-3, is a chemical compound characterized by its complex bicyclic structure, which includes a benzazepine core. This compound features a chloro substituent at the 7-position and a 2-methyl-4-nitrobenzoyl group, contributing to its unique chemical properties. It is typically a solid at room temperature and may exhibit moderate solubility in organic solvents, depending on the specific conditions. The presence of the nitro group suggests potential reactivity and the ability to participate in electrophilic aromatic substitution reactions. Additionally, the compound may possess biological activity, making it of interest in medicinal chemistry and pharmacology. Its specific interactions and effects would depend on further studies, including its mechanism of action and potential therapeutic applications. As with many organic compounds, safety data and handling precautions should be considered when working with this substance in a laboratory setting.

5H-1-Benzazepin-5-one, 7-chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-

CAS: 137982-91-3

Formula: C₁₈H₁₅ClN₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 358.7757

Ref: IN-DA0017RX

7-Chloro-1-(2-methyl-4-nitrobenzoyl)-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one

CAS: 137982-91-3

7-Chloro-1-(2-methyl-4-nitrobenzoyl)-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one

Purity: 98%

Molecular weight: 358.78g/mol

Ref: 54-OR1065373

Tolvaptan Impurity 12

CAS: 137982-91-3

Formula: C₁₈H₁₅ClN₂O₄

Color and Shape: White To Off-White Solid

Molecular weight: 358.78

Ref: 4Z-T-6917

7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one

Controlled Product

CAS: 137982-91-3

Applications 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one is an intermediate in synthesizing Tolvaptan-d7 (T536652), a labelled Tolvaptan (T536650). It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000); Udelson, J., et al.: Circulation, 104, 2417 (2001); Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005); Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006)

Formula: C₁₈H₁₅ClN₂O₄

Color and Shape: Neat

Molecular weight: 358.78

Ref: TR-C366123

Tolvaptan Impurity 12

CAS: 137982-91-3

Formula: C₁₈H₁₅ClN₂O₄

Molecular weight: 358.78

Ref: ST-EA-CP-T26020