CAS 138-39-6

Mafenide

Description:

Mafenide, with the CAS number 138-39-6, is a synthetic sulfonamide antibiotic primarily used in topical applications for the treatment of burns and skin infections. It is characterized by its ability to inhibit bacterial growth by interfering with folic acid synthesis, which is essential for bacterial proliferation. Mafenide is typically presented as a white to off-white crystalline powder that is soluble in water and has a slightly bitter taste. Its chemical structure features a sulfonamide group, which is responsible for its antimicrobial properties. The substance is often formulated as a cream or solution for direct application to affected areas. While effective against a range of gram-positive and gram-negative bacteria, it may cause local irritation or allergic reactions in some patients. Mafenide is particularly noted for its ability to penetrate eschar, making it valuable in burn care. However, its use may be limited by potential side effects, including metabolic acidosis and hypersensitivity reactions, necessitating careful monitoring during treatment.

Formula: C₇H₁₀N₂O₂S

InChI: InChI=1S/C7H10N2O2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,5,8H2,(H2,9,10,11)

InChI key: InChIKey=TYMRLRRVMHJFTF-UHFFFAOYSA-N

SMILES: S(N)(=O)(=O)C1=CC=C(CN)C=C1

Synonyms:

• 4-(Aminomethyl)benzene-1-sulfonamide
• 4-(Aminomethyl)benzenesulfonamide
• 4-(Aminosulfonyl)benzylamine
• 4-Homosulfanilamide
• 4-Sulfamoylbenzylamine
• Alpha-Aminotoluene-4-Sulphonamide
• Ambamide
• Benzamsulfonamide
• Benzenesulfonamide, 4-(aminomethyl)-
• Emilene
• Homonal
• Homosul
• Homosulfanilamide
• Malfamin
• Maphenid
• Maphenide
• Marprontil
• Mesudin
• Mesudrin
• NSC 34632
• Neofamid
• Paramenyl
• Septicid
• Sulfamylon
• p-(Aminomethyl)benzenesulfonamide
• p-Sulfamoylbenzylamine
• p-Toluenesulfonamide, α-amino-

Benzenesulfonamide, 4-(aminomethyl)-

CAS: 138-39-6

Formula: C₇H₁₀N₂O₂S

Purity: 96%

Color and Shape: Solid

Molecular weight: 186.2315

Ref: IN-DA0017T7

Mafenide

CAS: 138-39-6

Mafenide, a sulfonamide, inhibits the enzyme carbonic anhydrase and is used as a topical anti-infective drug, especially in burn therapy.

Formula: C₇H₁₀N₂O₂S

Color and Shape: Solid

Molecular weight: 186.23

Ref: TM-T21258

4-Aminomethylbenzenesulfonamide

CAS: 138-39-6

Formula: C₇H₁₀N₂O₂S

Purity: 95%

Color and Shape: Yellow solid

Molecular weight: 186.23

Ref: 10-F079312

4-Aminomethylbenzenesulfonamide

Controlled Product

CAS: 138-39-6

Applications 4-Aminomethylbenzenesulfonamide is useful for the synthesis of cytotoxic drugs as carbonic anhydrase inhibitors.
References van Kuijk, S. J., et al.: Eur. J. Med. Chem., 127, 691-702 (2017); Abdel-Aziz, A. A., et al.: Bioorg. Med. Chem., 25, 1666-1671 (2017)

Formula: C₇H₁₀N₂O₂S

Color and Shape: Neat

Molecular weight: 186.232

Ref: TR-A613490