CAS 1380288-87-8

Pinometostat

Description:

Pinometostat is a small molecule inhibitor primarily known for its role in targeting the enzyme DOT1L (disruptor of telomeric silencing 1-like), which is involved in the methylation of histone H3 at lysine 79. This compound has garnered attention in the field of cancer research, particularly for its potential therapeutic applications in treating acute leukemias, especially those associated with MLL (mixed lineage leukemia) gene rearrangements. Pinometostat exhibits characteristics typical of a targeted therapy, aiming to disrupt specific molecular pathways that contribute to tumorigenesis. Its mechanism of action involves inhibiting the aberrant histone methylation that promotes oncogenic gene expression. The compound has undergone various preclinical and clinical evaluations to assess its efficacy and safety profile. As with many investigational drugs, ongoing research is crucial to fully understand its pharmacokinetics, potential side effects, and overall therapeutic potential in oncology.

Formula: C₃₀H₄₂N₈O₃

InChI: InChI=1S/C30H42N8O3/c1-16(2)37(13-22-25(39)26(40)29(41-22)38-15-34-24-27(31)32-14-33-28(24)38)19-10-17(11-19)6-9-23-35-20-8-7-18(30(3,4)5)12-21(20)36-23/h7-8,12,14-17,19,22,25-26,29,39-40H,6,9-11,13H2,1-5H3,(H,35,36)(H2,31,32,33)/t17-,19+,22-,25-,26-,29-/m1/s1

InChI key: InChIKey=LXFOLMYKSYSZQS-LURJZOHASA-N

SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](CN(C(C)C)[C@H]4C[C@@H](CCC=5NC=6C(N5)=CC=C(C(C)(C)C)C6)C4)[C@H]1O

Synonyms:

• 9H-Purin-6-amine, 9-[5-deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-β-D-ribofuranosyl]-
• 5′-Deoxy-5′-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]adenosine
• Adenosine, 5′-deoxy-5′-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-
• EPZ 5676
• Pinometostat
• EPZ 005676
• 9-[5-Deoxy-5-[[cis-3-[2-[6-(1,1-diMethylethyl)-1H-benziMidazol-2-yl]ethyl]cyclobutyl](1-Methylethyl)aMino]-β-D-ribofuranosyl]-9H-purin-6-aMine
• (2R,3R,4S,5R)-2-(6-aMino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]iMidazol-2-yl)ethyl)cyclobutyl)(isopropyl)aMino)Methyl)tetrahydrofuran-3,4-diol
• 9-[5-Deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-beta-D-ribofuranosyl]-9H-purin-6-amine

(2R,3R,4S,5R)-2-(6-Amino-9H-purin-9-yl)-5-((((lr,3S)-3-(2-(5-(tert-butyl)-lH-benzo[d]imidazol2yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol

CAS: 1380288-87-8

Formula: C₃₀H₄₂N₈O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 562.7063

Ref: IN-DA0039K9

Pinometostat

CAS: 1380288-87-8

Pinometostat

Purity: ≥95%

Molecular weight: 562.71g/mol

Ref: 54-BUP16320

Pinometostat

CAS: 1380288-87-8

Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor. Pinometostat has antitumor activity. Cost effective and quality assured.

Formula: C₃₀H₄₂N₈O₃

Purity: 99.19% - 99.86%

Color and Shape: Solid

Molecular weight: 562.71

Ref: TM-T3099

9-[5-Deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-β-D-ribofuranosyl]-9H- purin-6-amine

CAS: 1380288-87-8

Nilotinib is a small molecule that inhibits the tyrosine kinase activity of TK1, TK2, and TK3. It binds to the ATP-binding site of these kinases and prevents the phosphorylation of the cellular substrate. Nilotinib has been shown to inhibit the proliferation of leukemia cells in vitro, as well as to have antiproliferative effects in vivo. Nilotinib can be used for the treatment of chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). In addition, it has been shown to have synergistic effects with other drugs such as α1-acid glycoprotein inhibitors or methyltransferase inhibitors. Nilotinib can also be used for cases of hepatic steatosis.

Formula: C₃₀H₄₂N₈O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 562.71 g/mol

Ref: 3D-FD146242

(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-{[(propan-2-yl)[(1r,3s)-3-[2-(6-tert-butyl-1H-1,3-benzodiazol-2-yl)ethyl]cyclobutyl]amino]methyl}oxolane-3,4-diol

CAS: 1380288-87-8

Purity: 98%

Molecular weight: 562.719

Ref: 10-F979323

9-[5-Deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-β-D-ribofuranosyl]-9H-purin-6-amine

Controlled Product

CAS: 1380288-87-8

Applications 9-[5-Deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-β-D-ribofuranosyl]-9H-purin-6-amine, can be used as an adenosine anticancer, and antibiotic analogues.
References Moukha-chafiq, O., et al.: American Chem. Soci., 146 (2013)

Formula: C₃₀H₄₂N₈O₃

Color and Shape: Neat

Molecular weight: 562.706

Ref: TR-D232835