CAS 1380288-87-8: Pinometostat
Description:Pinometostat is a small molecule inhibitor primarily known for its role in targeting the enzyme DOT1L (disruptor of telomeric silencing 1-like), which is involved in the methylation of histone H3 at lysine 79. This compound has garnered attention in the field of cancer research, particularly for its potential therapeutic applications in treating acute leukemias, especially those associated with MLL (mixed lineage leukemia) gene rearrangements. Pinometostat exhibits characteristics typical of a targeted therapy, aiming to disrupt specific molecular pathways that contribute to tumorigenesis. Its mechanism of action involves inhibiting the aberrant histone methylation that promotes oncogenic gene expression. The compound has undergone various preclinical and clinical evaluations to assess its efficacy and safety profile. As with many investigational drugs, ongoing research is crucial to fully understand its pharmacokinetics, potential side effects, and overall therapeutic potential in oncology.
Formula:C30H42N8O3
InChI:InChI=1S/C30H42N8O3/c1-16(2)37(13-22-25(39)26(40)29(41-22)38-15-34-24-27(31)32-14-33-28(24)38)19-10-17(11-19)6-9-23-35-20-8-7-18(30(3,4)5)12-21(20)36-23/h7-8,12,14-17,19,22,25-26,29,39-40H,6,9-11,13H2,1-5H3,(H,35,36)(H2,31,32,33)/t17-,19+,22-,25-,26-,29-/m1/s1
InChI key:InChIKey=LXFOLMYKSYSZQS-LURJZOHASA-N
SMILES:OC1C(O)C(OC1N2C=NC=3C(=NC=NC32)N)CN(C(C)C)C4CC(CCC5=NC=6C=CC(=CC6N5)C(C)(C)C)C4
- Synonyms:
- 9H-Purin-6-amine, 9-[5-deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-β-D-ribofuranosyl]-
- 5′-Deoxy-5′-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]adenosine
- Adenosine, 5′-deoxy-5′-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-
- EPZ 5676
- Pinometostat
- EPZ 005676
- 9-[5-Deoxy-5-[[cis-3-[2-[6-(1,1-diMethylethyl)-1H-benziMidazol-2-yl]ethyl]cyclobutyl](1-Methylethyl)aMino]-β-D-ribofuranosyl]-9H-purin-6-aMine
- (2R,3R,4S,5R)-2-(6-aMino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]iMidazol-2-yl)ethyl)cyclobutyl)(isopropyl)aMino)Methyl)tetrahydrofuran-3,4-diol
- 9-[5-Deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-beta-D-ribofuranosyl]-9H-purin-6-amine

(2R,3R,4S,5R)-2-(6-Amino-9H-purin-9-yl)-5-((((lr,3S)-3-(2-(5-(tert-butyl)-lH-benzo[d]imidazol2yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol
Ref: IN-DA0039K9
1mg | 74.00 € | ||
5mg | 175.00 € | ||
10mg | 196.00 € | ||
25mg | 549.00 € | ||
50mg | 530.00 € | ||
100mg | To inquire |

Pinometostat
Ref: TM-T3099
2mg | 40.00 € | ||
5mg | 60.00 € | ||
10mg | 88.00 € | ||
50mg | To inquire | ||
1mL*10mM (DMSO) | 74.00 € |

9-[5-Deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-beta-D-ribofuranosyl]-9H- purin-6-amine
Ref: 3D-FD146242
5mg | 193.00 € | ||
10mg | 330.00 € | ||
25mg | 613.00 € |

9-[5-Deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-β-D-ribofuranosyl]-9H-purin-6-amine
Controlled ProductRef: TR-D232835
100mg | 24,811.00 € |