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Pinometostat

CAS 1380288-87-8: Pinometostat

Description:Pinometostat is a small molecule inhibitor primarily known for its role in targeting the enzyme DOT1L (disruptor of telomeric silencing 1-like), which is involved in the methylation of histone H3 at lysine 79. This compound has garnered attention in the field of cancer research, particularly for its potential therapeutic applications in treating acute leukemias, especially those associated with MLL (mixed lineage leukemia) gene rearrangements. Pinometostat exhibits characteristics typical of a targeted therapy, aiming to disrupt specific molecular pathways that contribute to tumorigenesis. Its mechanism of action involves inhibiting the aberrant histone methylation that promotes oncogenic gene expression. The compound has undergone various preclinical and clinical evaluations to assess its efficacy and safety profile. As with many investigational drugs, ongoing research is crucial to fully understand its pharmacokinetics, potential side effects, and overall therapeutic potential in oncology.

Formula:C30H42N8O3

InChI:InChI=1S/C30H42N8O3/c1-16(2)37(13-22-25(39)26(40)29(41-22)38-15-34-24-27(31)32-14-33-28(24)38)19-10-17(11-19)6-9-23-35-20-8-7-18(30(3,4)5)12-21(20)36-23/h7-8,12,14-17,19,22,25-26,29,39-40H,6,9-11,13H2,1-5H3,(H,35,36)(H2,31,32,33)/t17-,19+,22-,25-,26-,29-/m1/s1

InChI key:InChIKey=LXFOLMYKSYSZQS-LURJZOHASA-N

SMILES:OC1C(O)C(OC1N2C=NC=3C(=NC=NC32)N)CN(C(C)C)C4CC(CCC5=NC=6C=CC(=CC6N5)C(C)(C)C)C4

  • Synonyms:
  • 9H-Purin-6-amine, 9-[5-deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-β-D-ribofuranosyl]-
  • 5′-Deoxy-5′-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]adenosine
  • Adenosine, 5′-deoxy-5′-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-
  • EPZ 5676
  • Pinometostat
  • EPZ 005676
  • 9-[5-Deoxy-5-[[cis-3-[2-[6-(1,1-diMethylethyl)-1H-benziMidazol-2-yl]ethyl]cyclobutyl](1-Methylethyl)aMino]-β-D-ribofuranosyl]-9H-purin-6-aMine
  • (2R,3R,4S,5R)-2-(6-aMino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]iMidazol-2-yl)ethyl)cyclobutyl)(isopropyl)aMino)Methyl)tetrahydrofuran-3,4-diol
  • 9-[5-Deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-beta-D-ribofuranosyl]-9H-purin-6-amine
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Found 4 products.

discount label

Ref: IN-DA0039K9

1mg74.00 €
5mg175.00 €
10mg196.00 €
25mg549.00 €
50mg530.00 €
100mgTo inquire
Estimated delivery in United States, on Wednesday 26 Mar 2025
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Pinometostat

CAS:1380288-87-8

Ref: TM-T3099

2mg40.00 €
5mg60.00 €
10mg88.00 €
50mgTo inquire
1mL*10mM (DMSO)74.00 €
Estimated delivery in United States, on Wednesday 2 Apr 2025
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9-[5-Deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-beta-D-ribofuranosyl]-9H- purin-6-amine

CAS:1380288-87-8

Ref: 3D-FD146242

5mg193.00 €
10mg330.00 €
25mg613.00 €
Estimated delivery in United States, on Tuesday 8 Apr 2025
discount label

9-[5-Deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-β-D-ribofuranosyl]-9H-purin-6-amine

Controlled Product
CAS:1380288-87-8

Ref: TR-D232835

100mg24,811.00 €
Estimated delivery in United States, on Tuesday 6 May 2025
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