CAS 138199-71-0: Levofloxacin hemihydrate
Description:Levofloxacin hemihydrate is a synthetic antibiotic belonging to the fluoroquinolone class, primarily used to treat a variety of bacterial infections. It is characterized by its broad-spectrum activity against both Gram-positive and Gram-negative bacteria, making it effective for respiratory tract infections, urinary tract infections, and skin infections. The hemihydrate form indicates that the compound contains one molecule of water for every two molecules of levofloxacin, which can influence its solubility and stability. Levofloxacin has a chiral center, and the levo- prefix denotes its S-enantiomer, which is the active form responsible for its antibacterial properties. The compound exhibits good oral bioavailability and is typically administered in tablet or intravenous form. Its mechanism of action involves inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication and repair. Common side effects may include gastrointestinal disturbances, central nervous system effects, and potential tendon damage. As with all antibiotics, appropriate use is essential to minimize the risk of resistance development.
Formula:C18H20FN3O4H2O
InChI:InChI=1S/C18H20FN3O4.H2O/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21;/h7-8,10H,3-6,9H2,1-2H3,(H,24,25);1H2/t10-;/m0./s1
InChI key:InChIKey=QEHPHWRZQAZOTI-PPHPATTJSA-N
SMILES:O=C(O)C1=CN2C3=C(OCC2C)C(=C(F)C=C3C1=O)N4CCN(C)CC4.O
- Synonyms:
- (-)-(S)-9-Fluoro-2,3-Dihydro-3-Methyl-10-(4-Methyl-1-Piperazinyl)-7-Oxo-7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid Hydrochloride
- (3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid hydrate
- (S)-(-)-Ofloxacine
- 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, hydrate (2:1), (3S)-
- 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, hydrate (2:1), (S)-
- Dynaquin
- Leeflox
- Levofloxacin hemihydrate
- Levofloxacin hydrate