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CAS 138370-14-6

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dynemicin Q

Description:
Dynemicin Q is a naturally occurring anthracycline antibiotic that exhibits notable antitumor properties. It is derived from the bacterium Micromonospora sp. and is characterized by its complex polycyclic structure, which includes a quinone moiety that contributes to its biological activity. The compound is known for its ability to intercalate into DNA, leading to the disruption of DNA replication and transcription, ultimately inducing apoptosis in cancer cells. Dynemicin Q is also recognized for its unique mechanism of action, which involves the generation of reactive oxygen species (ROS) that can further damage cellular components. Its chemical structure includes multiple functional groups that enhance its reactivity and interaction with biological macromolecules. Due to its potent cytotoxic effects, dynemicin Q has been the subject of research for potential therapeutic applications in oncology, although its clinical use is limited by factors such as toxicity and stability. Overall, dynemicin Q represents a significant compound in the field of medicinal chemistry, particularly in the development of novel anticancer agents.
Formula:C28H19NO9
InChI:InChI=1/C28H19NO9/c1-9-22(33)25(36)20-10-4-2-3-5-11(10)26-27(9,37)28(20,38)12-8-15(32)18-19(21(12)29-26)24(35)17-14(31)7-6-13(30)16(17)23(18)34/h2-8,20,26,29-33,37-38H,1H3
Synonyms:
  • dynemicin Q
  • 9,8,14-[2]Buten[1]yl[4]ylideneanthra[1,2-b]benz[f]azocine-5,6,20-trione, 8,9,14,15-tetrahydro-1,4,6,8,17,19-hexahydroxy-18-methyl-, (8R,9S,14S,17S)- (9CI)
  • 4a,13,14,14a-Tetrahydro-2,4a,6,8,11,14a-hexahydroxy-1-methyl-4,14-[1,2]benzenonaphtho[2,3-c]phenanthridine-3,7,12(4H)-trione
  • 1,4,6,8,17,19-hexahydroxy-18-methyl-8,9,14,15-tetrahydro-8,14,9-(but[2]ene[1,1,4]triyl)anthra[1,2-b]benzo[f]azocine-5,16,20-trione
  • 9,8,14-(2)Buten(1)yl(4)ylideneanthra(1,2-b)benz(f)azocine-5,6,20-trione, 8,9,14,15-tetrahydro-1,4,6,8,17,19-hexahydroxy-18-methyl-, (8R-(8alpha,9beta,14beta,17S*))-
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