CAS 13838-08-9

Azidamfenicol

Description:

Azidamfenicol is a synthetic antibiotic belonging to the class of chloramphenicol derivatives. It is characterized by its broad-spectrum antibacterial activity, making it effective against various Gram-positive and Gram-negative bacteria. The compound features an azido group, which contributes to its unique pharmacological properties. Azidamfenicol is typically used in veterinary medicine, particularly for treating infections in livestock and poultry. Its mechanism of action involves inhibiting bacterial protein synthesis by binding to the 50S ribosomal subunit, similar to chloramphenicol. This antibiotic is known for its potential to cause adverse effects, including bone marrow suppression, which necessitates careful monitoring during use. Additionally, due to its structural similarities to chloramphenicol, there are concerns regarding cross-resistance and the development of antibiotic resistance. As with many antibiotics, the use of Azidamfenicol is subject to regulatory scrutiny to ensure its safety and efficacy in both veterinary and potential human applications.

Formula: C₁₁H₁₃N₅O₅

InChI: InChI=1/C11H13N5O5/c12-15-13-5-10(18)14-9(6-17)11(19)7-1-3-8(4-2-7)16(20)21/h1-4,9,11,17,19H,5-6H2,(H,14,18)/t9-,11-/m1/s1

InChI key: InChIKey=SGRUZFCHLOFYHZ-MWLCHTKSSA-N

SMILES: [C@@H]([C@H](NC(CN=[N+]=[N-])=O)CO)(O)C1=CC=C(N(=O)=O)C=C1

Synonyms:

• 2-Azido-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide
• 2-azido-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
• <span class="text-smallcaps">D</span>-(-)-threo-1-p-Nitrophenyl-2-azidoacetylamino-1,3-propanediol
• Acetamide, 2-azido-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-
• Acetamide, 2-azido-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-, (R-(R*,R*))-
• Acetamide, 2-azido-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)-, D-threo-(-)-
• Acetamide, 2-azido-N-[β-hydroxy-α-(hydroxymethyl)-p-nitrophenethyl]-, <span class="text-smallcaps">D</span>-threo-(-)-
• Azidamfenicol [INN:BAN:DCF]
• Azidamfenicolum
• Azidamfenicolum [INN-Latin]
• Azidamphenicol
• Azidamphenicolum
• Azidanfenicol
• Azidanfenicol [INN-Spanish]
• Azidoamphenicol
• Bay f 4797
• Bayer 52910
• Berlicetin
• D(-)-threo-2-Azido-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)acetamide
• Leukomycin
• Leukomycin N
• Thilocanfol
• Thilocof
• Unii-40257685Lm
• threo-2-Azido-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)acetamide
• Acetamide, 2-azido-N-[β-hydroxy-α-(hydroxymethyl)-p-nitrophenethyl]-, D-threo-(-)-
• D-(-)-threo-1-p-Nitrophenyl-2-azidoacetylamino-1,3-propanediol
• AzidoaMphenicol, LeukoMycin N
• AZIAMPHENICOL, PHARMA
• azidamfenicol ISO 9001：2015 REACH

Azidamfenicol

CAS: 13838-08-9

Azidamfenicol

Purity: ≥98%

Molecular weight: 295.25g/mol

Ref: 54-BUP09016

Azidamfenicol

CAS: 13838-08-9

Formula: C₁₁H₁₃N₅O₅

Purity: ≥ 98.0%

Color and Shape: White solid

Molecular weight: 295.3

Ref: 7W-GA8560

Azidamfenicol

CAS: 13838-08-9

Applications Azidamfenicol is a semi-synthetic chloramphenicol.

Formula: C₁₁H₁₃N₅O₅

Color and Shape: White To Off-White

Molecular weight: 295.25

Ref: TR-A926853

Azidamfenicol

CAS: 13838-08-9

Azidamfenicol inhibits ribosomal peptidyltransferase with a Ki of 22 µM. Azidamfenicol is a broad-spectrum chloramphenicol-like antibiotic.

Formula: C₁₁H₁₃N₅O₅

Purity: 99.61%

Color and Shape: Solid

Molecular weight: 295.25

Ref: TM-T14391