CAS 1384516-10-2

N-(4-Chlorobenzyl)-1-(5-nitrothiophen-2-yl)methanamine

Controlled Product

CAS: 1384516-10-2

Applications N-(4-Chlorobenzyl)-1-(5-nitrothiophen-2-yl)methanamine is an analogue of GSK 4112 (G797700) which is a synthetic ligand for REV-ERBα, a member of the nuclear receptor superfamily that functions as a receptor for the porphoryin heme. GSK 4112 mimics the action of heme acting as agonist and suppresses the expression of REV-ERBα target genes involved in gluconeogenesis.
References Kojetin, D. et al.: ACS Chem. Biol., 6, 131 (2011); Grant, D. et al.: ACS Chem. Biol., 5, 925 (2010)

Formula: C₁₂H₁₁ClN₂O₂S

Color and Shape: Neat

Molecular weight: 282.746

Ref: TR-C364235