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CAS 138452-21-8

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Fexofenadine hydrochloride

Description:
Fexofenadine hydrochloride is a second-generation antihistamine primarily used to alleviate allergy symptoms such as hay fever and urticaria. It is a white to off-white crystalline powder that is practically insoluble in water but soluble in organic solvents like ethanol and methanol. The compound operates as a selective antagonist of peripheral H1 receptors, which helps reduce the effects of histamine, a substance in the body that causes allergic symptoms. Fexofenadine is known for its minimal sedative effects compared to first-generation antihistamines, making it a preferred choice for patients who require relief from allergies without significant drowsiness. The substance is typically administered orally and is available in various formulations, including tablets and suspension. Its pharmacokinetics indicate that it has a rapid onset of action, with peak plasma concentrations occurring within a few hours after ingestion. Additionally, fexofenadine is generally well-tolerated, with a low incidence of side effects, making it a widely used medication in allergy management.
Formula:C32H39NO4·ClH
InChI:InChI=1S/C32H39NO4.ClH/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27;/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36);1H
InChI key:InChIKey=RRJFVPUCXDGFJB-UHFFFAOYSA-N
SMILES:C(O)(C1CCN(CCCC(O)C2=CC=C(C(C(O)=O)(C)C)C=C2)CC1)(C3=CC=CC=C3)C4=CC=CC=C4.Cl
Synonyms:
  • 2-(4-[1-Hydroxy-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyl]phenyl)-2-methylpropanoic acid hydrochloride
  • 2-[4-(1-Hydroxy-4-{4-[Hydroxy(Diphenyl)Methyl]Piperidin-1-Yl}Butyl)Phenyl]-2-Methylpropanoic Acid Hydrochloride (1:1)
  • 2-[4-[1-Hydroxy-4-[4-(Hydroxy-Diphenyl-Methyl)-1-Piperidyl]-Butyl]Phenyl]-2-Methyl-Propanoic Acid Hydrochloride
  • Alernex
  • Allegra
  • Alpha,Alpha-Dimethyl-4-[1-Hydroxy-4-[4-(Hydroxydiphenylmethyl)-1-Piperidinyl]Butyl]-Benzeneacetic Acid Hydrochloride
  • Benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-, hydrochloride
  • Benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-, hydrochloride (1:1)
  • Carboxyterfenadine,Terfenadinecarboxylate
  • Fastofen
  • See more synonyms
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