CAS 138516-31-1

3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione acetate

Description:

The chemical substance known as 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione acetate, with the CAS number 138516-31-1, is a complex organic compound characterized by its indole and pyrrole moieties. This compound features a pyrrole-2,5-dione core, which is a diketopiperazine derivative, and is substituted with indole groups that contribute to its potential biological activity. The presence of an amino group on the propyl chain suggests possible interactions with biological targets, making it of interest in medicinal chemistry. The acetate group indicates that the compound may exist in a salt form, which can influence its solubility and stability. Overall, this substance may exhibit unique pharmacological properties, and its structural complexity suggests potential applications in drug development, particularly in the fields of oncology or neurology, where indole derivatives are often explored for therapeutic effects. Further studies would be necessary to elucidate its specific biological activities and mechanisms of action.

Formula: C₂₆H₂₆N₄O₄

InChI: InChI=1/C24H22N4O2.C2H4O2/c1-27-13-17(15-7-2-4-9-19(15)27)21-22(24(30)26-23(21)29)18-14-28(12-6-11-25)20-10-5-3-8-16(18)20;1-2(3)4/h2-5,7-10,13-14H,6,11-12,25H2,1H3,(H,26,29,30);1H3,(H,3,4)

SMILES: Cn1cc(c2ccccc12)C1=C(c2cn(CCCN)c3ccccc23)C(=O)N=C1O.CC(=O)O

Synonyms:

• 1H-pyrrole-2,5-dione, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-, acetate (1:1)

Bisindolylmaleimide VIII acetate

CAS: 138516-31-1

Bisindolylmaleimide VIII acetate is a selective PKC inhibitor with an IC50 of 158 nM in rat brain and varying IC50s for different PKC isoforms.

Formula: C₂₆H₂₆N₄O₄

Purity: 99.27%

Color and Shape: Solid

Molecular weight: 458.51

Ref: TM-T10549

1H-Pyrrole-2,5-dione, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-, acetate (1:1)

CAS: 138516-31-1

Formula: C₂₆H₂₆N₄O₄

Purity: 93%

Color and Shape: Solid

Molecular weight: 458.5090

Ref: IN-DA0019CR

Bisindolylmaleimide VIII acetate

CAS: 138516-31-1

Bisindolylmaleimide VIII acetate

Purity: ≥98%

Molecular weight: 458.51g/mol

Ref: 54-BUP02338

Bisindolylmaleimide VIII acetate salt

CAS: 138516-31-1

Bisindolylmaleimide VIII acetate salt

Purity: 97%

Molecular weight: 458.51g/mol

Ref: 54-BIMI0231

Bisindolylmaleimide VIII acetate salt

CAS: 138516-31-1

Formula: C₂₄H₂₂N₄O₂·CH₃COOH

Molecular weight: 458.6

Ref: 7W-GL4749

Bisindolylmaleimide VIII Acetic Acid Salt

Controlled Product

CAS: 138516-31-1

Applications It is a potent inhibitor of protein kinase C (PKC) activity. Bisindolylmaleimide VIII (Bis VIII) has been previously shown to enhance Fas-mediated apoptosis through a protein kinase C-independent mechanism.
References Emery, J., et al.: J. Biol. Chem., 273, 14363 (1998), Wiley, S., et al.: Immunity, 3, 673 (1995), MacFarlane, M., et al.: Biochem. J., 348, 93 (2000),

Formula: C₂₆H₂₆N₄O₄

Color and Shape: Neat

Molecular weight: 458.51

Ref: TR-B448500