CAS 138584-34-6

Losartan N1-Glucuronide

CAS: 138584-34-6

Formula: C₂₈H₃₁ClN₆O₇

Color and Shape: White To Off-White Solid

Molecular weight: 599.05

Ref: 4Z-L-1113

Losartan N1-glucuronide

CAS: 138584-34-6

Ref: 7W-GC2503

Losartan N1-Glucuronide

CAS: 138584-34-6

Applications A metabolite of Losartan (L470500).
References Stearns, R.A., et al.: Drug Metab. Dispos., 19, 1160 ( (1991), Chen, T.S., et al.: J. Antibiotics, 46, 131 (1993), Alonen, A., et al.: Bioorg. Chem., 36, 148 (2008),

Formula: C₂₈H₃₁ClN₆O₇

Color and Shape: Off-White to Pale Yellow Solid

Molecular weight: 599.03

Ref: TR-L470490

Losartan N1-glucuronide

CAS: 138584-34-6

Losartan N1-glucuronide is a glucuronidated metabolite of losartan that is produced naturally in the human body. It is converted from losartan by the enzyme UDP-glucuronosyltransferase, which is found in humans and other animals. The rate of glucuronidation varies between individuals and is determined by genetic factors. Losartan N1-glucuronide has shown to be an effective inhibitor of angiotensin II, with an IC50 value of 1.4 μM. This inhibition can be reversed by dobutamine or recombinant human UGT2B7 enzyme, which are both competitive inhibitors of the enzyme UGT2B7. Magnetic resonance spectroscopy has been used to study the kinetic properties of this inhibitor and its effect on dobutamine-induced changes in cardiac function.

Formula: C₂₈H₃₁ClN₆O₇

Purity: Min. 95%

Molecular weight: 599.03 g/mol

Ref: 3D-ML16776