The chemical substance with the name "his-lys-ala-arg-val-leu-P-nitro*phe-glu-ala-nle-S" and CAS number "138608-20-5" is a synthetic peptide that consists of a sequence of amino acids. This peptide features a variety of functional groups, including an aromatic nitro group, which can influence its biological activity and solubility. The presence of multiple amino acids suggests that it may have specific interactions with biological targets, potentially serving roles in research related to biochemistry or pharmacology. The sequence indicates a diverse range of properties, including hydrophilicity and hydrophobicity, which can affect its conformation and stability in solution. Additionally, the inclusion of non-standard amino acids, such as nle (norleucine), may impart unique characteristics that differentiate it from naturally occurring peptides. Overall, this compound's structure and composition suggest potential applications in drug development, molecular biology, or as a biochemical tool for studying protein interactions and functions.

his-lys-ala-arg-val-leu-P-nitro*phe-glu-ala-nle-S

138608-20-5: The chemical substance with the name "his-lys-ala-arg-val-leu-P-nitro*phe-glu-ala-nle-S" and CAS number "138608-20-5" is a synthetic peptide that consists of a sequence of amino acids. This peptide features a variety of functional groups, including an aromatic nitro group, which can influence its biological activity and solubility. The presence of multiple amino acids suggests that it may have specific interactions with biological targets, potentially serving roles in research related to biochemistry or pharmacology. The sequence indicates a diverse range of properties, including hydrophilicity and hydrophobicity, which can affect its conformation and stability in solution. Additionally, the inclusion of non-standard amino acids, such as nle (norleucine), may impart unique characteristics that differentiate it from naturally occurring peptides. Overall, this compound's structure and composition suggest potential applications in drug development, molecular biology, or as a biochemical tool for studying protein interactions and functions.

<p>HIV protease is a large protein that cleaves the polyprotein of HIV. This enzyme is essential for viral replication and so any drug that inhibits its function will inhibit HIV infectivity. The HIV protease substrate III, which contains histidine at position 3, has been used to study the effects of HIV proteases on different tissue types. It has been shown that this substrate can be detected in the cytoplasm and vacuole of cells infected with HIV, indicating that it may be involved in the transport process. The addition of an acidic amino acid (p-nitro-phenylalanine) to the substrate increases its antiviral activity by increasing its stability against proteolytic enzymes and allowing it to penetrate into cells more easily.</p>

CAS 138608-20-5

his-lys-ala-arg-val-leu-P-nitro*phe-glu-ala-nle-S

HIV Protease Substrate III

Ref: 3D-FH110373