CAS 138614-30-9

Icatibant acetate

Description:

Icatibant acetate is a synthetic peptide that functions as a selective bradykinin B2 receptor antagonist. It is primarily used in the treatment of hereditary angioedema, a condition characterized by recurrent episodes of severe swelling. The substance is known for its ability to inhibit the action of bradykinin, a peptide that promotes vasodilation and increases vascular permeability, thereby reducing the symptoms associated with angioedema. Icatibant acetate is administered via subcutaneous injection and is characterized by its relatively rapid onset of action. The compound is typically formulated as a sterile solution for injection and has a specific molecular structure that contributes to its pharmacological activity. Its safety profile has been established through clinical trials, and it is generally well-tolerated, although some patients may experience injection site reactions or other mild side effects. Overall, Icatibant acetate represents a significant advancement in the management of hereditary angioedema, providing patients with an effective therapeutic option.

Formula: C₅₉H₈₉N₁₉O₁₃S・xC₂H₄O₂

InChI: InChI=1/C59H89N19O13S.C2H4O2/c60-37(14-5-19-67-57(61)62)48(82)72-38(15-6-20-68-58(63)64)52(86)75-22-8-18-43(75)54(88)77-30-35(80)26-44(77)50(84)70-28-47(81)71-40(27-36-13-9-23-92-36)49(83)74-41(31-79)53(87)76-29-34-12-2-1-10-32(34)24-46(76)55(89)78-42-17-4-3-11-33(42)25-45(78)51(85)73-39(56(90)91)16-7-21-69-59(65)66;1-2(3)4/h1-2,9-10,12-13,23,33,35,37-46,79-80H,3-8,11,14-22,24-31,60H2,(H,70,84)(H,71,81)(H,72,82)(H,73,85)(H,74,83)(H,90,91)(H4,61,62,67)(H4,63,64,68)(H4,65,66,69);1H3,(H,3,4)/t33-,35+,37+,38?,39-,40-,41-,42-,43?,44?,45?,46?;/m0./s1

Synonyms:

• Hoe 140
• (R)-Arginyl-(S)-arginyl-(S)-prolyl-(2S,4R)-(4-hydroxyprolyl)glycyl-(S)-(3-(2-thienyl)alanyl)-(S)-seryl-(R)-((1,2,3,4-tetrahydro-3-isoquinolyl)carbonyl)-(2S,3aS,7aS)-((hexahydro-2-indolinyl)carbonyl)-(S)-arginine acetate (salt)
• L-Arginine, D-arginyl-L-arginyl-L-prolyl-trans-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2alpha,3abeta,7abeta)-octahydro-1H-indole-2-carbonyl-, acetate (salt)

L-Arginine, D-arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-(3R)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-(2S,3aS,7aS)-octahydro-1H-indole-2-carbonyl-, acetate (salt)

CAS: 138614-30-9

Formula: C₆₁H₉₃N₁₉O₁₅S

Purity: 98%

Color and Shape: Solid

Molecular weight: 1364.5744

Ref: IN-DA0018VS

Icatibant Acetate

CAS: 138614-30-9

Icatibant Acetate

Purity: ≥98%

Molecular weight: 1364.57g/mol

Ref: 54-BUP03567

Icatibant acetate

CAS: 138614-30-9

Formula: C₆₁H₉₃N₁₉O₁₅S

Purity: (HPLC) ≥ 95.0%

Color and Shape: White to almost white powder

Molecular weight: 1364.57

Ref: 7W-GK9272

Icatibant Acetate

CAS: 138614-30-9

Icatibant Acetate, an antagonist of the bradykinin B2 receptor, is used in the treatment of hereditary angioedema.

Formula: C₆₁H₉₃N₁₉O₁₅S

Purity: 99.68%

Color and Shape: Solid

Molecular weight: 1364.57

Ref: TM-T22344

Icatibant Acetate

CAS: 138614-30-9

Applications Icatibant Acetate is a bradykinin B2 receptor antagonist that has been recently approved for treatment of acute attacks of hereditary angioedema (HAE).
References Greve, J., et al.: Int. J. Dermatol., 50, 1294 (2011); Cole, S.W., et al.: Ann. Pharmacother., 47, 49 (2013)

Formula: C₅₉H₈₉N₁₉O₁₃S·x(C₂H₄O₂)

Color and Shape: Neat

Molecular weight: 1304.54 + x(60.05)

Ref: TR-I163750

Icatibant acetate

CAS: 138614-30-9

Icatibant is a 10 amino acid peptidomimetic of bradykinin and a selective antagonist to the bradykinin B2 receptor. Icabinant has been used for the treatment of attacks in patients with hereditary angioedema. Recent evidence has shown a link between dysregulated bradykinin‐mediated inflammation and acute respiratory distress syndrome (ARDS), a common complication in COVID-19 patients. Icatibant was proposed to inhibit excessive activation of the bradykinin B2 receptor during the SARS-CoV-2 infection, reducing the risk of ARDS.

Formula: C₅₉H₈₉N₁₉O₁₃S•(C₂H₄O₂)x

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 1,304.52 g/mol

Ref: 3D-FI146277