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CAS 138680-92-9

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HOE 140, desArg(10)-

Description:
HOE 140, also known as desArg(10)-CGRP, is a synthetic peptide that acts as a selective antagonist for the calcitonin gene-related peptide (CGRP) receptor. This compound is characterized by its ability to inhibit the action of CGRP, a neuropeptide involved in various physiological processes, including vasodilation and pain transmission. HOE 140 is often studied in the context of migraine research and cardiovascular regulation due to its role in modulating vascular tone and inflammatory responses. The chemical structure of HOE 140 includes specific amino acid sequences that confer its biological activity, and it is typically administered in research settings to explore its pharmacological effects. Its CAS number, 138680-92-9, uniquely identifies this compound in chemical databases, facilitating its study and application in scientific research. Overall, HOE 140 serves as an important tool in understanding the mechanisms of CGRP and its implications in various health conditions.
Formula:C53H77N15O12S
InChI:InChI=1/C53H77N15O12S/c54-32(12-4-17-61-50(56)57)45(75)65-34(13-5-18-62-51(58)59)48(78)68-20-6-14-37(68)41(72)31-11-3-15-38-52(31,39(71)25-64-47(77)35-22-28(70)24-63-35)43(42(73)40-30-10-2-1-8-27(30)16-19-60-40)53(67-38,49(79)80)44(74)36(26-69)66-46(76)33(55)23-29-9-7-21-81-29/h7,9,16,19,21,28,31-38,43,63,67,69-70H,1-6,8,10-15,17-18,20,22-26,54-55H2,(H,64,77)(H,65,75)(H,66,76)(H,79,80)(H4,56,57,61)(H4,58,59,62)/t28?,31?,32-,33+,34+,35+,36+,37+,38+,43?,52+,53+/m1/s1
Synonyms:
  • Bradykinin, arginyl-(hydroxypropyl(3)-3-thienylalanyl(5)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl(7)-octahydro-1H-indole-2-carbonyl(8))-desarginyl(9)-
  • Arg-(3-hyp-5-thi-7-tic-9-oic)-9-desarg-bradykinin
  • Darg(hyp(3)-thi(5)-dtic(7)-oic(8))desarg(9)-BK
  • D-Arg(hyp(3)-thi(5)-D-tic(7)-oic(8)-desarg(10))BK
  • Hoe 140, desarginyl(10)-
  • 10-Desarg-hoe 140
  • Bradykinin, arg-(hyp(3)-thi(5)-tic(7)-oic(8))-desarg(9)-
  • L-Alaninamide, D-arginyl-L-arginyl-L-prolyl-trans-4-hydroxy-L-prolylglycyl-N-(2-(3-((2-carboxyoctahydro-1H-indol-1-yl)carbonyl)-3,4-dihydro-2(1H)-isoquinolinyl)-1-(hydroxymethyl)-2-oxoethyl)-3-(2-thienyl)-, (2S-(1(S*(R*)),2alpha,3abeta,7abeta))-
  • Hoe 140, desarg(10)-
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