CAS 13870-90-1: Coenzyme B12
Description:Coenzyme B12, also known as methylcobalamin, is a vital cofactor in various biochemical processes, particularly in the metabolism of homocysteine and the synthesis of methionine. It is a water-soluble vitamin belonging to the B-vitamin complex, specifically the B12 group, which includes several forms of cobalamin. Characterized by its complex structure, coenzyme B12 contains a cobalt ion at its core, coordinated to a corrin ring, and is distinguished by the presence of a methyl group. This compound plays a crucial role in cellular metabolism, particularly in the central nervous system and in the formation of red blood cells. Deficiency in coenzyme B12 can lead to significant health issues, including anemia and neurological disorders. It is primarily obtained through dietary sources, particularly animal products, and is essential for maintaining proper neurological function and DNA synthesis. Additionally, coenzyme B12 is often used in clinical settings to treat deficiencies and related health conditions.
Formula:C72H100CoN18O17P
InChI:InChI=1S/C62H90N13O14P.C10H12N5O3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);2-4,6-7,10,16-17H,1H2,(H2,11,12,13);/q;-1;+3/p-2/t31-,34-,35-,36-,37+,41-,52?,53-,56-,57+,59-,60+,61+,62+;4-,6-,7-,10-;/m11./s1
InChI key:InChIKey=OAJLVMGLJZXSGX-RQKYJTTQSA-L
SMILES:O=C(N)CCC1C=2C=C3[N]4=C(C(=C5[N-]6C7C(CC(=O)N)C5(C)CCC(=O)NCC(OP(=O)([O-])OC8C(O)C(OC8CO)N9C=[N](C=%10C=C(C(=CC%109)C)C)[Co+3]4%116([N]2C(=C(C%12=[N]%11C7(C)C(C)(CC(=O)N)C%12CCC(=O)N)C)C1(C)CC(=O)N)[CH2-]C%13OC(N%14C=NC=%15C(=NC=NC%15%14)N)C(O)C%13O)C)C)C(CCC(=O)N)C3(C)C
- Synonyms:
- (5'-Deoxy-5'-adenosyl)cobamide coenzyme
- (5,6-Dimethylbenzimidazolyl)Cobamide Coenzyme
- 5'-Deoxy-5'-adenosylcobalamin
- 5'-Deoxyadenosyl vitamin B12
- 5'-Deoxyadenosyl-5,6-dimethylbenzimidazolylcobamide
- 5'-Deoxyadenosylcobalamin
- 5,6-Dimethylbenzimidazolyl-5-deoxyadenosyl-cobamide
- 5,6-Dimethylbenzimidazolyl-Co-5'-deoxyadenosylcobamide
- 5′-Deoxyadenosyl vitamin B<sub>12</sub>
- Actimide
- See more synonyms
- Adenosyl B12
- Adenosyl B<sub>12</sub>
- Adenosylcobalamin
- Anabasi
- Betarin
- Calomide
- Cobalamin coenzyme
- Cobalamin, Co-(5'-deoxy-5'-adenosyl)-
- Cobalion
- Cobamamid
- Cobamamida
- Cobamamide
- Cobamide coenzyme, (5'-deoxy-5'-adenosyl)-
- Cobamide coenzyme, (5,6-dimethyl-1H-benzimidazolyl)-
- Cobamide, Co-(5'-deoxy-5'-adenosyl)-α-(5,6-dimethyl-1H-benzimidazolyl)-
- Cobanzyme
- Cobatlamin S
- Cobazymase
- Cobinamide, Co-(5'-deoxyadenosine-5') deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole
- Cobinamide, Co-(5'-deoxyadenosine-5') deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-α-D-ribofuranosylbenzimidazole
- Cobinamide, Co-(5'-deoxyadenosine-5') derivative hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole
- Cobinamide, Co-(5′-deoxyadenosin-5′-yl)-, f-(dihydrogen phosphate), inner salt, 3′-ester with (5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-benzimidazole-κN<sup>3</sup>)
- Cobinamide, Co-(5′-deoxyadenosine-5′) deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3′-ester with 5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-benzimidazole
- Cobinamide, Co-(5′-deoxyadenosine-5′) deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3′-ester with 5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosylbenzimidazole
- Coenzile
- Coenzyme B12
- Coenzyme B<sub>12</sub>
- DBC
- DBC coenzyme
- Dbcc
- Deoxyadenosylcobalamin
- Dibencozide
- Dibenzcozamide
- Dimebenzcozamide
- Dolonevran
- Enzicoba
- Funacomide
- Heraclene
- Hi-Fresmin
- Hycobal
- Indusil
- Lm 176
- Represil
- Sabalamin
- Vitamin B12 coenzyme
- Vitamin B12, Co-(5'-deoxy-5'-adenosyl) deriv.
- Vitamin B<sub>12</sub> coenzyme
- Vitamin B<sub>12</sub>, Co-(5′-deoxy-5′-adenosyl) deriv.
- Xobaline
- α-(5,6-Dimethylbenzimidazolyl)-Co-5'-deoxyadenosylcobamide
- α-(5,6-Dimethylbenzimidazolyl)cobamide coenzyme
- coenzyme B12 crystalline
- Cobinamide, Co-(5′-deoxyadenosin-5′-yl)-, f-(dihydrogen phosphate), inner salt, 3′-ester with (5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole-κN3)
- adenosyl cobalamine
