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CAS 138775-07-2

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Fmoc-Orn(Z)-OH

Description:
Fmoc-Orn(Z)-OH, or 9-fluorenylmethoxycarbonyl-ornithine (Z)-hydroxyl, is a protected amino acid derivative commonly used in peptide synthesis. The "Fmoc" group serves as a protective group for the amino functionality, allowing for selective reactions without interfering with other functional groups. The "Orn" refers to ornithine, a non-proteinogenic amino acid, while the "(Z)" indicates that the side chain amine is protected with a benzyloxycarbonyl (Z) group, which is stable under standard peptide coupling conditions. This compound is typically utilized in solid-phase peptide synthesis, where the protection of functional groups is crucial for the sequential addition of amino acids. Fmoc-Orn(Z)-OH is characterized by its stability under basic conditions, ease of removal of the Fmoc group under mild conditions (usually with a base), and its ability to form peptide bonds with other amino acids. Its applications extend to the synthesis of bioactive peptides and research in medicinal chemistry, particularly in the development of peptide-based therapeutics.
Formula:C28H28N2O6
Synonyms:
  • N-Alpha-Fmoc-N-Delta-Benzyloxycarbonyl-L-Ornithine
  • N-Alpha-(9-Fluorenylmethoxycarbonyl)L-N-Delta-Carbobenzoxy-L-Ornithine
  • N-Alpha-(9-Fluorenylmethyloxycarbonyl)-N-Delta-Benzyloxycarbonyl-L-Ornithine
  • Fmoc-N-Delta-Z-L-Ornithine
  • Fmoc-L-Orn(Z)-Oh
  • Fmoc-Orn(Cbz)-Oh
  • Fmoc-N-S-Z-L-Ornithine
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